Influence of macrolide antibiotics on promotion of resistance in the oral flora of children

The long elimination half-life of azithromycin allows subinhibitory serum and epithelial lining fluid (ELF) concentrations over a period of several weeks post treatment, which may have an impact on the emergence of macrolide resistance. In this prospective, open-label, randomized study, four macroli...

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Veröffentlicht in:	Infection 2001-10, Vol.29 (5), p.251-256
Hauptverfasser:	KASTNER, U, GUGGENBICHLER, J. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Azithromycin - pharmacokinetics Azithromycin - pharmacology Biological and medical sciences Child Child, Preschool Drug Resistance, Bacterial Female Flora Haemophilus influenzae - drug effects Haemophilus influenzae - pathogenicity Half-Life Humans Infant Male Medical sciences Mouth - microbiology Pharmacology. Drug treatments Prospective Studies Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - pathogenicity Respiratory tract Selection, Genetic
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