DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway

DOC-2/hDab-2 was identified due to the loss of its expression in primary ovarian cancer cells. It is believed that loss of DOC-2/hDab-2 expression is one of the early events of ovarian malignancy. These results suggest a function of DOC-2/hDab-2 as a tumor suppressor. However, it is not clear how DO...

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Veröffentlicht in:	Oncogene 2001-10, Vol.20 (47), p.6960-6964
Hauptverfasser:	WANG, Shao-Chun, MAKINO, Keishi, WEIYA XIA, JEONG SOO KIM, IM, Seock-Ah, HUA PENG, MOK, Samuel C, SINGLETARY, Sonja E, HUNG, Mien-Chie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Adenoviridae - genetics Adenoviruses Akt gene AKT protein Anoikis Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell adhesion molecules Cell culture Cell death Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DOC-2 gene Female Fundamental and applied biological sciences. Psychology Genes, Tumor Suppressor Genetic Vectors hDab-2 gene Humans ILK protein Infections integrin-linked kinase Integrins Kinases Malignancy MAP Kinase Signaling System Molecular and cellular biology Oncology Ovarian cancer Protein-Serine-Threonine Kinases - antagonists & inhibitors Proteins Proteins - genetics Proteins - physiology Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt Signal Transduction Transfection Tumor Cells, Cultured Tumor suppressor genes Tumor Suppressor Proteins Tumors Womens health
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