Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteo...
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| Veröffentlicht in: | Nature medicine 2000-09, Vol.6 (9), p.980-984 |
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| creator | Wagner, Erwin F Jochum, Wolfram David, Jean-Pierre Elliott, Candace Wutz, Anton Plenk, Hanns Matsuo, Koichi |
| description | Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated
in vitro
. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions. |
| doi_str_mv | 10.1038/79676 |
| format | Article |
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in vitro
. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/79676</identifier><identifier>PMID: 10973316</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Bones ; Calcinosis - genetics ; Cancer Research ; Cell Differentiation ; Extracellular matrix ; fra-1 gene ; Infectious Diseases ; Metabolic Diseases ; Mice ; Mice, Transgenic ; Molecular Medicine ; Neurosciences ; Osteoblasts - cytology ; Osteoblasts - metabolism ; osteosclerosis ; Osteosclerosis - genetics ; Pathology ; Phenotype ; Proteins ; Proto-Oncogene Proteins c-fos - biosynthesis ; Proto-Oncogene Proteins c-fos - genetics ; Transcription factors ; Transgenic animals</subject><ispartof>Nature medicine, 2000-09, Vol.6 (9), p.980-984</ispartof><rights>Nature America Inc. 2000</rights><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5446-b0a51df85df963d3e8e323d20aaf325221e1324936cb851fda5d270b459300bc3</citedby><cites>FETCH-LOGICAL-c5446-b0a51df85df963d3e8e323d20aaf325221e1324936cb851fda5d270b459300bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10973316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wagner, Erwin F</creatorcontrib><creatorcontrib>Jochum, Wolfram</creatorcontrib><creatorcontrib>David, Jean-Pierre</creatorcontrib><creatorcontrib>Elliott, Candace</creatorcontrib><creatorcontrib>Wutz, Anton</creatorcontrib><creatorcontrib>Plenk, Hanns</creatorcontrib><creatorcontrib>Matsuo, Koichi</creatorcontrib><title>Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated
in vitro
. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bones</subject><subject>Calcinosis - genetics</subject><subject>Cancer Research</subject><subject>Cell Differentiation</subject><subject>Extracellular matrix</subject><subject>fra-1 gene</subject><subject>Infectious Diseases</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Molecular Medicine</subject><subject>Neurosciences</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - metabolism</subject><subject>osteosclerosis</subject><subject>Osteosclerosis - genetics</subject><subject>Pathology</subject><subject>Phenotype</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Proto-Oncogene Proteins c-fos - 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Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagner, Erwin F</au><au>Jochum, Wolfram</au><au>David, Jean-Pierre</au><au>Elliott, Candace</au><au>Wutz, Anton</au><au>Plenk, Hanns</au><au>Matsuo, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2000-09</date><risdate>2000</risdate><volume>6</volume><issue>9</issue><spage>980</spage><epage>984</epage><pages>980-984</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated
in vitro
. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>10973316</pmid><doi>10.1038/79676</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Bones Calcinosis - genetics Cancer Research Cell Differentiation Extracellular matrix fra-1 gene Infectious Diseases Metabolic Diseases Mice Mice, Transgenic Molecular Medicine Neurosciences Osteoblasts - cytology Osteoblasts - metabolism osteosclerosis Osteosclerosis - genetics Pathology Phenotype Proteins Proto-Oncogene Proteins c-fos - biosynthesis Proto-Oncogene Proteins c-fos - genetics Transcription factors Transgenic animals |
| title | Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1 |
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