Galanin-1 receptor up-regulation mediates the excess colonic fluid production caused by infection with enteric pathogens

Galanin is widely distributed in enteric nerve terminals lining the gastrointestinal tract. We previously showed that pathogenic Escherichia coli, but not normal commensal organisms, increase galanin-1 receptor expression by epithelial cells lining the colon (i.e., colonocytes). When present, galani...

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