Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells

Purpose: To investigate the impact of γ-irradiation on cyclooxygenase-2 (COX-2) expression and its enzymatic activity in PC-3 cells. Cell cycle redistribution, viability, and apoptosis were quantitated in control and irradiated cells with or without the COX-2 inhibitor NS-398. Methods and Materials:...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2000-09, Vol.48 (2), p.325-328
Hauptverfasser:	Steinauer, Kirsten K, Gibbs, Iris, Ning, Shoucheng, French, John N, Armstrong, Jeff, Knox, Susan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Biological and medical sciences Biological effects of radiation Biomarkers Blotting, Western Cell Cycle - physiology Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Dinoprostone - metabolism Diseases of the urinary system Enzyme Activation - drug effects Enzyme Activation - radiation effects Fundamental and applied biological sciences. Psychology Gamma Rays Humans Ionizing radiations Isoenzymes - metabolism Isoenzymes - radiation effects Male Medical sciences Membrane Proteins Nitrobenzenes - pharmacology NS-398 Prostaglandin E 2 Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandin-Endoperoxide Synthases - radiation effects Prostate cancer Radiation Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sulfonamides - pharmacology Time Factors Tissues, organs and organisms biophysics Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - radiation effects Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!