Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA

NTAK (neural- and thymus-derived activator for the ErbB kinase, neuregulin-2) is a novel member of the epidermal growth factor (EGF) family. We have isolated and characterized the human NTAK gene, comprising 12 exons spanning in excess of 55 kilobases (kb). The 7.0 kb long mRNA of the human NTAK gen...

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Veröffentlicht in:	Gene 2000-09, Vol.255 (1), p.15-24
Hauptverfasser:	Yamada, Kouji, Ichino, Naohiro, Nishii, Kazuhiro, Sawada, Hirohide, Higashiyama, Shigeki, Ishiguro, Hiroshi, Nagatsu, Toshiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Southern Brain - metabolism DNA - chemistry DNA - genetics DNA - isolation & purification EGF ErbB Exons Female Gene Expression Genes - genetics Genomic structure Humans Introns Isoform Male Molecular Sequence Data Nerve Growth Factors - genetics neural- and thymus-derived activator for the ErbB kinase Neuregulin neuregulin-2 NTAK NTAK gene PC12 Cells Promoter Regions, Genetic Protein Isoforms - genetics Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Analysis, DNA Sequence Homology, Nucleic Acid TFIIA protein Tissue Distribution Transcription, Genetic Tumor Cells, Cultured YY1 protein
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