Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show t...

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Veröffentlicht in:Nature medicine 2000-09, Vol.6 (9), p.1036-1042
Hauptverfasser: Hazenberg, Mette D., Otto, Sigrid A., Stuart, James W.T. Cohen, Verschuren, Martie C.M., Borleffs, Jan C.C., Boucher, Charles A.B., Coutinho, Roel A., Lange, Joep M.A., de Wit, Tobias F. Rinke, Tsegaye, Aster, van Dongen, Jacques J.M., Hamann, Dörte, de Boer, Rob J., Miedema, Frank
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Sprache:eng
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