Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas
To clarify p21(waf1/cip1) expression in sinonasal lesions. Archived surgical specimens from 38 patients were investigated by means of immunohistochemistry. p21(waf1/cip1) staining was evaluated in the different layers of the epithelium. In addition, human papillomavirus (HPV) infection and p53 prote...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical pathology 2001-11, Vol.54 (11), p.871-876 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 876 |
|---|---|
| container_issue | 11 |
| container_start_page | 871 |
| container_title | Journal of clinical pathology |
| container_volume | 54 |
| creator | Schwerer, M J Sailer, A Kraft, K Baczako, K Maier, H |
| description | To clarify p21(waf1/cip1) expression in sinonasal lesions.
Archived surgical specimens from 38 patients were investigated by means of immunohistochemistry. p21(waf1/cip1) staining was evaluated in the different layers of the epithelium. In addition, human papillomavirus (HPV) infection and p53 protein overexpression were assessed and correlated with p21(waf1/cip1) expression.
p21(waf1/cip1) staining was negative in non-papillomatous nasal mucosa. HPV infection and p53 protein overexpression were not seen. Sixteen of 20 inverted papillomas showed p21(waf1/cip1) expression. HPV infection was found in 16 cases and p53 protein overexpression was present in 13 specimens. Expression of p21(waf1/cip1) was restricted to surface cells in five cases, but involved basal/parabasal cells in 11 specimens. Immunoreactivity for p21(waf1/cip1) in basal/parabasal cells colocalised with p53 protein overexpression. Enhanced expression rates for p21(waf1/cip1) were seen in transitional and squamous epithelium compared with columnar epithelium. p21(waf1/cip1) expression involved only surface cells in cylindrical cell papillomas. HPV infection and p53 protein overexpression were detected in all specimens. One of five squamous cell carcinomas showed p21(waf1/cip1) expression. HPV infection was seen in two cases, and all carcinomas showed p53 protein overexpression.
Expression of p21(waf1/cip1) is associated with terminal differentiation in surface cells in inverted papillomas and cylindrical cell papillomas, but not in non-papillomatous nasal mucosa. Overexpression of p53 protein colocalises with p21(waf1/cip1) expression in basal/parabasal cells in inverted papillomas but not in cylindrical cell papillomas. Expression of p21(waf1/cip1) in squamous cell carcinomas involves a subset of tumours with p53 protein overexpression. |
| doi_str_mv | 10.1136/jcp.54.11.871 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72240180</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72240180</sourcerecordid><originalsourceid>FETCH-LOGICAL-p207t-cb59f41a75cf22d54ae730cb27efd582cef5b4ad78470f091ed8981bb5a243803</originalsourceid><addsrcrecordid>eNo9kEtLw0AUhWeh2FpdupVZiULTziudZCnFFxR0oetwMw-cksyMmQTt2j9uqNXVPXC-c-EchC4oWVDKV8utiotcjHpRSHqEpoQwmpVSrCboNKUtIZRLyk_QhNJVISTjU_T9An1vOp9wsDgyev0Jli6Vi_QGm6_YmZRc8Nh57IPPIkTXNKGFPgwJe0jQ4HZQIcEcG69DfN_1TuHkRnhv_gfSHIPXGFIKykFvNFbQqZEbrTN0bKFJ5vxwZ-jt_u51_Zhtnh-e1rebLDIi-0zVeWkFBZkry5jOBRjJiaqZNFbnBVPG5rUALcdqxJKSGl2UBa3rHJjgBeEzdPX7N3bhYzCpr1qXlGka8GbsU0nGBKF78PIADnVrdBU710K3q_5m4z_vXW-L</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72240180</pqid></control><display><type>article</type><title>Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas</title><source>PubMed Central Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Schwerer, M J ; Sailer, A ; Kraft, K ; Baczako, K ; Maier, H</creator><creatorcontrib>Schwerer, M J ; Sailer, A ; Kraft, K ; Baczako, K ; Maier, H</creatorcontrib><description>To clarify p21(waf1/cip1) expression in sinonasal lesions.
Archived surgical specimens from 38 patients were investigated by means of immunohistochemistry. p21(waf1/cip1) staining was evaluated in the different layers of the epithelium. In addition, human papillomavirus (HPV) infection and p53 protein overexpression were assessed and correlated with p21(waf1/cip1) expression.
p21(waf1/cip1) staining was negative in non-papillomatous nasal mucosa. HPV infection and p53 protein overexpression were not seen. Sixteen of 20 inverted papillomas showed p21(waf1/cip1) expression. HPV infection was found in 16 cases and p53 protein overexpression was present in 13 specimens. Expression of p21(waf1/cip1) was restricted to surface cells in five cases, but involved basal/parabasal cells in 11 specimens. Immunoreactivity for p21(waf1/cip1) in basal/parabasal cells colocalised with p53 protein overexpression. Enhanced expression rates for p21(waf1/cip1) were seen in transitional and squamous epithelium compared with columnar epithelium. p21(waf1/cip1) expression involved only surface cells in cylindrical cell papillomas. HPV infection and p53 protein overexpression were detected in all specimens. One of five squamous cell carcinomas showed p21(waf1/cip1) expression. HPV infection was seen in two cases, and all carcinomas showed p53 protein overexpression.
Expression of p21(waf1/cip1) is associated with terminal differentiation in surface cells in inverted papillomas and cylindrical cell papillomas, but not in non-papillomatous nasal mucosa. Overexpression of p53 protein colocalises with p21(waf1/cip1) expression in basal/parabasal cells in inverted papillomas but not in cylindrical cell papillomas. Expression of p21(waf1/cip1) in squamous cell carcinomas involves a subset of tumours with p53 protein overexpression.</description><identifier>ISSN: 0021-9746</identifier><identifier>DOI: 10.1136/jcp.54.11.871</identifier><identifier>PMID: 11684723</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Aged ; Biomarkers - analysis ; Carcinoma, Squamous Cell - chemistry ; Carcinoma, Squamous Cell - virology ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins - analysis ; Female ; Humans ; Immunohistochemistry - methods ; Male ; Middle Aged ; Nasal Mucosa - chemistry ; Neoplasm Proteins - analysis ; Nose Neoplasms - chemistry ; Nose Neoplasms - pathology ; Nose Neoplasms - virology ; Papilloma - chemistry ; Papilloma - pathology ; Papilloma - virology ; Papillomaviridae ; Papillomavirus Infections - complications ; Papillomavirus Infections - diagnosis ; Paranasal Sinus Neoplasms - chemistry ; Paranasal Sinus Neoplasms - pathology ; Paranasal Sinus Neoplasms - virology ; Tumor Suppressor Protein p53 - analysis</subject><ispartof>Journal of clinical pathology, 2001-11, Vol.54 (11), p.871-876</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11684723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwerer, M J</creatorcontrib><creatorcontrib>Sailer, A</creatorcontrib><creatorcontrib>Kraft, K</creatorcontrib><creatorcontrib>Baczako, K</creatorcontrib><creatorcontrib>Maier, H</creatorcontrib><title>Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>To clarify p21(waf1/cip1) expression in sinonasal lesions.
Archived surgical specimens from 38 patients were investigated by means of immunohistochemistry. p21(waf1/cip1) staining was evaluated in the different layers of the epithelium. In addition, human papillomavirus (HPV) infection and p53 protein overexpression were assessed and correlated with p21(waf1/cip1) expression.
p21(waf1/cip1) staining was negative in non-papillomatous nasal mucosa. HPV infection and p53 protein overexpression were not seen. Sixteen of 20 inverted papillomas showed p21(waf1/cip1) expression. HPV infection was found in 16 cases and p53 protein overexpression was present in 13 specimens. Expression of p21(waf1/cip1) was restricted to surface cells in five cases, but involved basal/parabasal cells in 11 specimens. Immunoreactivity for p21(waf1/cip1) in basal/parabasal cells colocalised with p53 protein overexpression. Enhanced expression rates for p21(waf1/cip1) were seen in transitional and squamous epithelium compared with columnar epithelium. p21(waf1/cip1) expression involved only surface cells in cylindrical cell papillomas. HPV infection and p53 protein overexpression were detected in all specimens. One of five squamous cell carcinomas showed p21(waf1/cip1) expression. HPV infection was seen in two cases, and all carcinomas showed p53 protein overexpression.
Expression of p21(waf1/cip1) is associated with terminal differentiation in surface cells in inverted papillomas and cylindrical cell papillomas, but not in non-papillomatous nasal mucosa. Overexpression of p53 protein colocalises with p21(waf1/cip1) expression in basal/parabasal cells in inverted papillomas but not in cylindrical cell papillomas. Expression of p21(waf1/cip1) in squamous cell carcinomas involves a subset of tumours with p53 protein overexpression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - analysis</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Cyclin-Dependent Kinase Inhibitor p21</subject><subject>Cyclins - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasal Mucosa - chemistry</subject><subject>Neoplasm Proteins - analysis</subject><subject>Nose Neoplasms - chemistry</subject><subject>Nose Neoplasms - pathology</subject><subject>Nose Neoplasms - virology</subject><subject>Papilloma - chemistry</subject><subject>Papilloma - pathology</subject><subject>Papilloma - virology</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Paranasal Sinus Neoplasms - chemistry</subject><subject>Paranasal Sinus Neoplasms - pathology</subject><subject>Paranasal Sinus Neoplasms - virology</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><issn>0021-9746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AUhWeh2FpdupVZiULTziudZCnFFxR0oetwMw-cksyMmQTt2j9uqNXVPXC-c-EchC4oWVDKV8utiotcjHpRSHqEpoQwmpVSrCboNKUtIZRLyk_QhNJVISTjU_T9An1vOp9wsDgyev0Jli6Vi_QGm6_YmZRc8Nh57IPPIkTXNKGFPgwJe0jQ4HZQIcEcG69DfN_1TuHkRnhv_gfSHIPXGFIKykFvNFbQqZEbrTN0bKFJ5vxwZ-jt_u51_Zhtnh-e1rebLDIi-0zVeWkFBZkry5jOBRjJiaqZNFbnBVPG5rUALcdqxJKSGl2UBa3rHJjgBeEzdPX7N3bhYzCpr1qXlGka8GbsU0nGBKF78PIADnVrdBU710K3q_5m4z_vXW-L</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Schwerer, M J</creator><creator>Sailer, A</creator><creator>Kraft, K</creator><creator>Baczako, K</creator><creator>Maier, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas</title><author>Schwerer, M J ; Sailer, A ; Kraft, K ; Baczako, K ; Maier, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-cb59f41a75cf22d54ae730cb27efd582cef5b4ad78470f091ed8981bb5a243803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - analysis</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Cyclin-Dependent Kinase Inhibitor p21</topic><topic>Cyclins - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasal Mucosa - chemistry</topic><topic>Neoplasm Proteins - analysis</topic><topic>Nose Neoplasms - chemistry</topic><topic>Nose Neoplasms - pathology</topic><topic>Nose Neoplasms - virology</topic><topic>Papilloma - chemistry</topic><topic>Papilloma - pathology</topic><topic>Papilloma - virology</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - diagnosis</topic><topic>Paranasal Sinus Neoplasms - chemistry</topic><topic>Paranasal Sinus Neoplasms - pathology</topic><topic>Paranasal Sinus Neoplasms - virology</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwerer, M J</creatorcontrib><creatorcontrib>Sailer, A</creatorcontrib><creatorcontrib>Kraft, K</creatorcontrib><creatorcontrib>Baczako, K</creatorcontrib><creatorcontrib>Maier, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwerer, M J</au><au>Sailer, A</au><au>Kraft, K</au><au>Baczako, K</au><au>Maier, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>54</volume><issue>11</issue><spage>871</spage><epage>876</epage><pages>871-876</pages><issn>0021-9746</issn><abstract>To clarify p21(waf1/cip1) expression in sinonasal lesions.
Archived surgical specimens from 38 patients were investigated by means of immunohistochemistry. p21(waf1/cip1) staining was evaluated in the different layers of the epithelium. In addition, human papillomavirus (HPV) infection and p53 protein overexpression were assessed and correlated with p21(waf1/cip1) expression.
p21(waf1/cip1) staining was negative in non-papillomatous nasal mucosa. HPV infection and p53 protein overexpression were not seen. Sixteen of 20 inverted papillomas showed p21(waf1/cip1) expression. HPV infection was found in 16 cases and p53 protein overexpression was present in 13 specimens. Expression of p21(waf1/cip1) was restricted to surface cells in five cases, but involved basal/parabasal cells in 11 specimens. Immunoreactivity for p21(waf1/cip1) in basal/parabasal cells colocalised with p53 protein overexpression. Enhanced expression rates for p21(waf1/cip1) were seen in transitional and squamous epithelium compared with columnar epithelium. p21(waf1/cip1) expression involved only surface cells in cylindrical cell papillomas. HPV infection and p53 protein overexpression were detected in all specimens. One of five squamous cell carcinomas showed p21(waf1/cip1) expression. HPV infection was seen in two cases, and all carcinomas showed p53 protein overexpression.
Expression of p21(waf1/cip1) is associated with terminal differentiation in surface cells in inverted papillomas and cylindrical cell papillomas, but not in non-papillomatous nasal mucosa. Overexpression of p53 protein colocalises with p21(waf1/cip1) expression in basal/parabasal cells in inverted papillomas but not in cylindrical cell papillomas. Expression of p21(waf1/cip1) in squamous cell carcinomas involves a subset of tumours with p53 protein overexpression.</abstract><cop>England</cop><pmid>11684723</pmid><doi>10.1136/jcp.54.11.871</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9746 |
| ispartof | Journal of clinical pathology, 2001-11, Vol.54 (11), p.871-876 |
| issn | 0021-9746 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72240180 |
| source | PubMed Central Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Biomarkers - analysis Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - virology Cyclin-Dependent Kinase Inhibitor p21 Cyclins - analysis Female Humans Immunohistochemistry - methods Male Middle Aged Nasal Mucosa - chemistry Neoplasm Proteins - analysis Nose Neoplasms - chemistry Nose Neoplasms - pathology Nose Neoplasms - virology Papilloma - chemistry Papilloma - pathology Papilloma - virology Papillomaviridae Papillomavirus Infections - complications Papillomavirus Infections - diagnosis Paranasal Sinus Neoplasms - chemistry Paranasal Sinus Neoplasms - pathology Paranasal Sinus Neoplasms - virology Tumor Suppressor Protein p53 - analysis |
| title | Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T06%3A50%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Patterns%20of%20p21(waf1/cip1)%20expression%20in%20non-papillomatous%20nasal%20mucosa,%20endophytic%20sinonasal%20papillomas,%20and%20associated%20carcinomas&rft.jtitle=Journal%20of%20clinical%20pathology&rft.au=Schwerer,%20M%20J&rft.date=2001-11-01&rft.volume=54&rft.issue=11&rft.spage=871&rft.epage=876&rft.pages=871-876&rft.issn=0021-9746&rft_id=info:doi/10.1136/jcp.54.11.871&rft_dat=%3Cproquest_pubme%3E72240180%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72240180&rft_id=info:pmid/11684723&rfr_iscdi=true |