Production of pyruvate by Candida albicans: proposed role in virulence

Abstract Proposed herein is a mechanism for virulence by Candida albicans based upon this organism's ability to produce high levels of pyruvate, potentially resulting in localized tissue ketosis and undermining the normal defensive function of neutrophil myeloperoxidase. Neutrophils, a key comp...

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Veröffentlicht in:	FEMS microbiology letters 2000-09, Vol.190 (1), p.35-38
1. Verfasser:	Saeed, Fawzia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetoacetate Acetoacetates - metabolism Bacteriology Biological and medical sciences Candida albicans Candida albicans - growth & development Candida albicans - metabolism Candida albicans - pathogenicity Culture Media - chemistry Fundamental and applied biological sciences. Psychology Growth, nutrition, cell differenciation Humans Hydrogen Peroxide - metabolism Ketones Ketosis Lactobacillus acidophilus - growth & development Lactobacillus acidophilus - metabolism Leukocytes (neutrophilic) Microbiology Microorganisms Myeloperoxidase Neutrophils Peroxidase Peroxidase - metabolism Phagocytosis Pyruvates - metabolism Pyruvic acid Virulence Virulence factors
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