Total synthesis and antifungal evaluation of cyclic aminohexapeptides

The need for new therapies to treat systemic fungal infections continues to rise. Naturally occurring hexapeptide echinocandin B (1) has shown potent antifungal activity via its inhibition of the synthesis of beta-1,3 glucan, a key fungal cell wall component. Although this series of agents has been...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2000-07, Vol.8 (7), p.1677-1696
Hauptverfasser:	KLEIN, L. L, LEPING LI, KISHORE, V, LUNDELL, E. O, WODKA, D, MEULBROEK, J. A, ALDER, J. D, NILIUS, A. M, LARTEY, P. A, PLATTNER, J. J, CHEN, H.-J, CURTY, C. B, DEGOEY, D. A, GRAMPOVNIK, D. J, LEONE, C. L, THOMAS, S. A, YEUNG, C. M, FUNK, K. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Amines - chemical synthesis Amines - chemistry Amines - pharmacology Amphotericin B - pharmacology Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Candida - drug effects Candidiasis, Vulvovaginal - drug therapy Candidiasis, Vulvovaginal - microbiology Disease Models, Animal Dose-Response Relationship, Drug Echinocandins Female Fungal Proteins Medical sciences Mice Microbial Sensitivity Tests Peptides Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Proline - chemistry Solubility Structure-Activity Relationship Yeasts - drug effects
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