Adaptive hitchhiking effects on genome variability
The continuing deluge of nucleotide polymorphism data is providing insights into the role of adaptation in shaping genome-wide patterns of variability and molecular evolution. Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave ‘footp...
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| Veröffentlicht in: | Current Opinion in Genetics & Development 2001-12, Vol.11 (6), p.635-641 |
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| creator | Andolfatto, Peter |
| description | The continuing deluge of nucleotide polymorphism data is providing insights into the role of adaptation in shaping genome-wide patterns of variability and molecular evolution. Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave ‘footprints’ in closely linked genomic regions. New analytical approaches show promise for distinguishing the signature of adaptation from that of several non-adaptive alternatives. Accounting for the effects of population structure and history poses a challenge for future investigations. |
| doi_str_mv | 10.1016/S0959-437X(00)00246-X |
| format | Article |
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Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave ‘footprints’ in closely linked genomic regions. New analytical approaches show promise for distinguishing the signature of adaptation from that of several non-adaptive alternatives. 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Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave ‘footprints’ in closely linked genomic regions. New analytical approaches show promise for distinguishing the signature of adaptation from that of several non-adaptive alternatives. Accounting for the effects of population structure and history poses a challenge for future investigations.</description><subject>adaptation</subject><subject>Adaptation, Biological - genetics</subject><subject>Animals</subject><subject>background selection</subject><subject>Chromosomes - genetics</subject><subject>deleterious mutations</subject><subject>demography</subject><subject>Drosophila</subject><subject>Evolution, Molecular</subject><subject>Gene Frequency</subject><subject>Genetic Linkage</subject><subject>Genetic Variation</subject><subject>human</subject><subject>Humans</subject><subject>linkage</subject><subject>Mutation</subject><subject>polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Probability</subject><subject>Recombination, Genetic - genetics</subject><subject>Selection, Genetic</subject><subject>selective sweep</subject><issn>0959-437X</issn><issn>1879-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EouXxCaCsECwCYzt2nBWqKl5SJRaA1J3lOuPWkCbFTiv170kfgiWLmdmcO6M5hFxQuKVA5d0bFKJIM56PrwFuAFgm0_EB6VOVFylwBYek_4v0yEmMn9BRlMpj0uu6Yhxkn7BBaRatX2Ey862dzfyXr6cJOoe2jUlTJ1OsmzkmKxO8mfjKt-szcuRMFfF8P0_Jx-PD-_A5Hb0-vQwHo9RySdu0pMxImlPLqRPcMWGkVbZgyiopGZrcZZaXEjIljBHSCueUyFDSwmEOUvFTcrXbuwjN9xJjq-c-WqwqU2OzjDpnjHdFO1DsQBuaGAM6vQh-bsJaU9AbWXorS29MaAC9laXHXe5yf2A5mWP5l9rb6YD7HYDdmyuPQUfrsbZY-tD50WXj_znxA7IxeRI</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Andolfatto, Peter</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Adaptive hitchhiking effects on genome variability</title><author>Andolfatto, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-d12a6171c31f53f25a6c8c928c8662ea7f4c3d60485aa56c5ff854e619fe70683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>adaptation</topic><topic>Adaptation, Biological - genetics</topic><topic>Animals</topic><topic>background selection</topic><topic>Chromosomes - genetics</topic><topic>deleterious mutations</topic><topic>demography</topic><topic>Drosophila</topic><topic>Evolution, Molecular</topic><topic>Gene Frequency</topic><topic>Genetic Linkage</topic><topic>Genetic Variation</topic><topic>human</topic><topic>Humans</topic><topic>linkage</topic><topic>Mutation</topic><topic>polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Probability</topic><topic>Recombination, Genetic - genetics</topic><topic>Selection, Genetic</topic><topic>selective sweep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andolfatto, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Genetics & Development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andolfatto, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adaptive hitchhiking effects on genome variability</atitle><jtitle>Current Opinion in Genetics & Development</jtitle><addtitle>Curr Opin Genet Dev</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>11</volume><issue>6</issue><spage>635</spage><epage>641</epage><pages>635-641</pages><issn>0959-437X</issn><eissn>1879-0380</eissn><abstract>The continuing deluge of nucleotide polymorphism data is providing insights into the role of adaptation in shaping genome-wide patterns of variability and molecular evolution. Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave ‘footprints’ in closely linked genomic regions. New analytical approaches show promise for distinguishing the signature of adaptation from that of several non-adaptive alternatives. Accounting for the effects of population structure and history poses a challenge for future investigations.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11682306</pmid><doi>10.1016/S0959-437X(00)00246-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Current Opinion in Genetics & Development, 2001-12, Vol.11 (6), p.635-641 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | adaptation Adaptation, Biological - genetics Animals background selection Chromosomes - genetics deleterious mutations demography Drosophila Evolution, Molecular Gene Frequency Genetic Linkage Genetic Variation human Humans linkage Mutation polymorphism Polymorphism, Genetic - genetics Probability Recombination, Genetic - genetics Selection, Genetic selective sweep |
| title | Adaptive hitchhiking effects on genome variability |
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