The 4G/4G genotype at nucleotide position −675 in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene is less frequent in young patients with minor stroke than in controls
Genetic risk factors play an important role in the aetiology of vascular diseases. The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patient...
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| Veröffentlicht in: | British journal of haematology 2000-08, Vol.110 (2), p.469-471 |
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| container_title | British journal of haematology |
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| creator | Endler, G. Lalouschek, W. Exner, M. Mitterbauer, G. Häring, D. Mannhalter, C. |
| description | Genetic risk factors play an important role in the aetiology of vascular diseases. The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patients with minor stroke (MS) and transient ischaemic attack (TIA) and found a prevalence of 0·32 for the 4G/4G genotype in patients compared with 0·42 in 115 age‐matched healthy controls. The 4G/4G genotype was significantly less frequent among 61 patients symptomatic before the age of 60 years (prevalence 0·20) than in 75 patients symptomatic after 60 years of age (prevalence 0·42; odds ratio). Our results indicate that the 4G/4G genotype is not a risk factor for MS or TIA and may even be protective in young patients. |
| doi_str_mv | 10.1046/j.1365-2141.2000.02164.x |
| format | Article |
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The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patients with minor stroke (MS) and transient ischaemic attack (TIA) and found a prevalence of 0·32 for the 4G/4G genotype in patients compared with 0·42 in 115 age‐matched healthy controls. The 4G/4G genotype was significantly less frequent among 61 patients symptomatic before the age of 60 years (prevalence 0·20) than in 75 patients symptomatic after 60 years of age (prevalence 0·42; odds ratio). Our results indicate that the 4G/4G genotype is not a risk factor for MS or TIA and may even be protective in young patients.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2000.02164.x</identifier><identifier>PMID: 10971410</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>4G/5G promotor polymorphism ; Biological and medical sciences ; Case-Control Studies ; Female ; genetic risk factors ; Genotype ; Humans ; Male ; Medical sciences ; Middle Aged ; minor stroke ; Neurology ; PAI‐1 ; Plasminogen Activator Inhibitor 1 - genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Risk Factors ; Stroke - genetics ; transient ischaemic attack ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>British journal of haematology, 2000-08, Vol.110 (2), p.469-471</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4444-2c40d8d097007e73eeb896614ddf1e907f54e6a13b76a396ef9f9017638d08bc3</citedby><cites>FETCH-LOGICAL-c4444-2c40d8d097007e73eeb896614ddf1e907f54e6a13b76a396ef9f9017638d08bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2141.2000.02164.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2141.2000.02164.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1479668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10971410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Endler, G.</creatorcontrib><creatorcontrib>Lalouschek, W.</creatorcontrib><creatorcontrib>Exner, M.</creatorcontrib><creatorcontrib>Mitterbauer, G.</creatorcontrib><creatorcontrib>Häring, D.</creatorcontrib><creatorcontrib>Mannhalter, C.</creatorcontrib><title>The 4G/4G genotype at nucleotide position −675 in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene is less frequent in young patients with minor stroke than in controls</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Genetic risk factors play an important role in the aetiology of vascular diseases. The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patients with minor stroke (MS) and transient ischaemic attack (TIA) and found a prevalence of 0·32 for the 4G/4G genotype in patients compared with 0·42 in 115 age‐matched healthy controls. The 4G/4G genotype was significantly less frequent among 61 patients symptomatic before the age of 60 years (prevalence 0·20) than in 75 patients symptomatic after 60 years of age (prevalence 0·42; odds ratio). Our results indicate that the 4G/4G genotype is not a risk factor for MS or TIA and may even be protective in young patients.</description><subject>4G/5G promotor polymorphism</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>genetic risk factors</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>minor stroke</subject><subject>Neurology</subject><subject>PAI‐1</subject><subject>Plasminogen Activator Inhibitor 1 - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Promoter Regions, Genetic</subject><subject>Risk Factors</subject><subject>Stroke - genetics</subject><subject>transient ischaemic attack</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhiMEotvCKyAfEKKHpHbsdZIDh1LBtqgSHMrZcpzJrpfEXmyHdm8cOSLeiRfpk2CTFXDEF1sz3z_jmT_LEMEFwYyfbQtC-TIvCSNFiTEucEk4K-4eZIs_iYfZImaqPArqo-zY-y3GhOIleZwdEdxUEcGL7OfNBhBbnbEVWoOxYb8DJAMykxrABt0B2lmvg7YG3X_7wasl0gaFqNk5O9pgHXKwTlnbz-FB-lEbG4shqYL-IhOjzUa3Or0Ievnh_Or-63dymhoC0h4N4D3qHXyewIRUf28ns0Y7GXQMeHSrwwalog754OwniJ2kSaCyJgYG_yR71MvBw9PDfZJ9fPvm5uIyv36_uro4v84ViycvFcNd3cXh42KgogBt3XBOWNf1BBpc9UsGXBLaVlzShkPf9A0mFadRVLeKnmQv5rpx-vhbH8SovYJhkAbs5EVVljTuiEawnkHlrPcOerFzepRuLwgWyUKxFckpkZwSyULx20JxF6XPDj2mdoTuH-HsWQSeHwDplRx6J43S_i_HqjhTHbFXM3arB9j_d3_x-t1letFfDQi6fA</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>Endler, G.</creator><creator>Lalouschek, W.</creator><creator>Exner, M.</creator><creator>Mitterbauer, G.</creator><creator>Häring, D.</creator><creator>Mannhalter, C.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200008</creationdate><title>The 4G/4G genotype at nucleotide position −675 in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene is less frequent in young patients with minor stroke than in controls</title><author>Endler, G. ; Lalouschek, W. ; Exner, M. ; Mitterbauer, G. ; Häring, D. ; Mannhalter, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4444-2c40d8d097007e73eeb896614ddf1e907f54e6a13b76a396ef9f9017638d08bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>4G/5G promotor polymorphism</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>genetic risk factors</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>minor stroke</topic><topic>Neurology</topic><topic>PAI‐1</topic><topic>Plasminogen Activator Inhibitor 1 - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Promoter Regions, Genetic</topic><topic>Risk Factors</topic><topic>Stroke - genetics</topic><topic>transient ischaemic attack</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Endler, G.</creatorcontrib><creatorcontrib>Lalouschek, W.</creatorcontrib><creatorcontrib>Exner, M.</creatorcontrib><creatorcontrib>Mitterbauer, G.</creatorcontrib><creatorcontrib>Häring, D.</creatorcontrib><creatorcontrib>Mannhalter, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Endler, G.</au><au>Lalouschek, W.</au><au>Exner, M.</au><au>Mitterbauer, G.</au><au>Häring, D.</au><au>Mannhalter, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The 4G/4G genotype at nucleotide position −675 in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene is less frequent in young patients with minor stroke than in controls</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2000-08</date><risdate>2000</risdate><volume>110</volume><issue>2</issue><spage>469</spage><epage>471</epage><pages>469-471</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Genetic risk factors play an important role in the aetiology of vascular diseases. The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patients with minor stroke (MS) and transient ischaemic attack (TIA) and found a prevalence of 0·32 for the 4G/4G genotype in patients compared with 0·42 in 115 age‐matched healthy controls. The 4G/4G genotype was significantly less frequent among 61 patients symptomatic before the age of 60 years (prevalence 0·20) than in 75 patients symptomatic after 60 years of age (prevalence 0·42; odds ratio). Our results indicate that the 4G/4G genotype is not a risk factor for MS or TIA and may even be protective in young patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10971410</pmid><doi>10.1046/j.1365-2141.2000.02164.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 4G/5G promotor polymorphism Biological and medical sciences Case-Control Studies Female genetic risk factors Genotype Humans Male Medical sciences Middle Aged minor stroke Neurology PAI‐1 Plasminogen Activator Inhibitor 1 - genetics Polymerase Chain Reaction Polymorphism, Genetic Promoter Regions, Genetic Risk Factors Stroke - genetics transient ischaemic attack Vascular diseases and vascular malformations of the nervous system |
| title | The 4G/4G genotype at nucleotide position −675 in the promotor region of the plasminogen activator inhibitor 1 (PAI‐1) gene is less frequent in young patients with minor stroke than in controls |
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