Immunosuppression with FK506 Increases Bone Induction in Demineralized Isogeneic and Xenogeneic Bone Matrix in the Rat

The aim of the present study was to investigate a systemic induction of bone formation in rats by immunosuppression with FK506 (1 mg/kg body weight intraperitoneally [ip]) in a model of osteoinduction of isogeneic and xenogeneic demineralized bone matrix (DBM) for a period of 28 days. In particular,...

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Veröffentlicht in:	Journal of bone and mineral research 2000-09, Vol.15 (9), p.1825-1834
Hauptverfasser:	Voggenreiter, Gregor, Assenmacher, Stefan, Kreuzfelder, Ernst, Wolf, Markus, Kim, Mi‐Ran, Nast‐Kolb, Dieter, Schade, Fritz Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Antigens, CD - analysis Biological and medical sciences Body Weight Bone Development - drug effects Bone Development - immunology bone histomorphometry Bone Matrix - drug effects Bone Matrix - immunology Bone Matrix - metabolism Bone Matrix - transplantation Bone Resorption - drug therapy Bone Resorption - immunology Calcification, Physiologic - drug effects Calcification, Physiologic - immunology Cell Differentiation - drug effects Cytokines - biosynthesis demineralized bone matrix FK506 Fundamental and applied biological sciences. Psychology immunosuppression Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Lymphocyte Subsets - cytology Lymphocyte Subsets - drug effects Lymphocyte Subsets - immunology osteoinduction Rabbits Rats Rats, Inbred Strains Skeleton and joints T lymphocytes Tacrolimus - blood Tacrolimus - pharmacology Tacrolimus - therapeutic use Tibia - drug effects Tibia - physiology Transplantation, Heterologous - immunology Transplantation, Isogeneic - immunology Vertebrates: osteoarticular system, musculoskeletal system
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