Tumor Suppression by a Proapoptotic Calcium-activated Chloride Channel in Mammary Epithelium

Little is known of the roles played by ion channels in cancer. Here we describe a pair of closely related calcium-activated chloride channels whose differential regulation in normal, apoptotic, and transformed mouse cells suggests that channel function is proapoptotic and antineoplastic. While mCLCA...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (44), p.40510-40517
Hauptverfasser:	Elble, Randolph C., Pauli, Bendicht U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis Base Sequence Calcium - metabolism Cell Line Chloride Channels - genetics Chloride Channels - metabolism CLCA1 protein CLCA2 protein Cloning, Molecular DNA Primers Epithelial Cells - metabolism Humans Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Molecular Sequence Data Sequence Homology, Amino Acid Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!