Subclinical hyperthyroidism as a risk factor for atrial fibrillation
Objectives Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically euthyroid persons is a risk factor for subsequent at...
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| Veröffentlicht in: | The American heart journal 2001-11, Vol.142 (5), p.838-842 |
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| creator | Auer, Johann Scheibner, Peter Mische, Thomas Langsteger, Werner Eber, Otto Eber, Bernd |
| description | Objectives Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically euthyroid persons is a risk factor for subsequent atrial fibrillation. Methods We studied 23,638 persons. The subjects were classified according to their serum thyrotropin concentrations: group 1 comprised those with normal values of serum thyrotropin concentration (>0.4-5.0 mU/L) and free tri-iodothyronine and free thyroxine concentrations were within the normal range (22,300 subjects), group 2 comprised those with both low serum thyrotropin values (≤0.03 mU/L) and elevated free tri-iodothyronine and free thyroxine concentrations (725 subjects), and group 3 comprised those with low values of serum thyrotropin ( |
| doi_str_mv | 10.1067/mhj.2001.119370 |
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We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically euthyroid persons is a risk factor for subsequent atrial fibrillation. Methods We studied 23,638 persons. The subjects were classified according to their serum thyrotropin concentrations: group 1 comprised those with normal values of serum thyrotropin concentration (>0.4-5.0 mU/L) and free tri-iodothyronine and free thyroxine concentrations were within the normal range (22,300 subjects), group 2 comprised those with both low serum thyrotropin values (≤0.03 mU/L) and elevated free tri-iodothyronine and free thyroxine concentrations (725 subjects), and group 3 comprised those with low values of serum thyrotropin (<0.4 mU/L) and free triiodothyronine and free thyroxine concentrations were within the normal range (613 subjects). Results Atrial fibrillation was present in 513 persons (2.3%) in group 1 with normal values for serum thyrotropin, 100 (13.8%) in group 2 with overt hyperthyroidism, and 78 (12.7%) in group 3 with subclinical hyperthyroidism. The prevalence of atrial fibrillation in patients with low serum thyrotropin concentrations (<0.4 mU/L) was 13.3% compared with 2.3% in patients with normal values for serum thyrotropin (P <.01). The relative risk of atrial fibrillation in subjects with low serum thyrotropin and normal free tri-iodothyronine and free thyroxine concentrations, compared with those with normal concentrations of serum thyrotropin, was 5.2 (95% CI 2.1-8.7, P <.01). Conclusion A low serum thyrotropin concentration is associated with a >5-fold higher likelihood for the presence of atrial fibrillation with no significant difference between subclinical and overt hyperthyroidism. (Am Heart J 2001;142:838-42.)</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1067/mhj.2001.119370</identifier><identifier>PMID: 11685172</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Atrial Fibrillation - blood ; Atrial Fibrillation - epidemiology ; Biological and medical sciences ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Comorbidity ; Heart ; Humans ; Hyperthyroidism - blood ; Hyperthyroidism - epidemiology ; Medical sciences ; Middle Aged ; Risk Factors ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>The American heart journal, 2001-11, Vol.142 (5), p.838-842</ispartof><rights>2001 Mosby, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-384ebf00beffcb8955bb96811a54c2f63147641dc0465e23b2f2d678a2f353343</citedby><cites>FETCH-LOGICAL-c439t-384ebf00beffcb8955bb96811a54c2f63147641dc0465e23b2f2d678a2f353343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002870301888098$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14130383$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11685172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auer, Johann</creatorcontrib><creatorcontrib>Scheibner, Peter</creatorcontrib><creatorcontrib>Mische, Thomas</creatorcontrib><creatorcontrib>Langsteger, Werner</creatorcontrib><creatorcontrib>Eber, Otto</creatorcontrib><creatorcontrib>Eber, Bernd</creatorcontrib><title>Subclinical hyperthyroidism as a risk factor for atrial fibrillation</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Objectives Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically euthyroid persons is a risk factor for subsequent atrial fibrillation. Methods We studied 23,638 persons. The subjects were classified according to their serum thyrotropin concentrations: group 1 comprised those with normal values of serum thyrotropin concentration (>0.4-5.0 mU/L) and free tri-iodothyronine and free thyroxine concentrations were within the normal range (22,300 subjects), group 2 comprised those with both low serum thyrotropin values (≤0.03 mU/L) and elevated free tri-iodothyronine and free thyroxine concentrations (725 subjects), and group 3 comprised those with low values of serum thyrotropin (<0.4 mU/L) and free triiodothyronine and free thyroxine concentrations were within the normal range (613 subjects). Results Atrial fibrillation was present in 513 persons (2.3%) in group 1 with normal values for serum thyrotropin, 100 (13.8%) in group 2 with overt hyperthyroidism, and 78 (12.7%) in group 3 with subclinical hyperthyroidism. The prevalence of atrial fibrillation in patients with low serum thyrotropin concentrations (<0.4 mU/L) was 13.3% compared with 2.3% in patients with normal values for serum thyrotropin (P <.01). The relative risk of atrial fibrillation in subjects with low serum thyrotropin and normal free tri-iodothyronine and free thyroxine concentrations, compared with those with normal concentrations of serum thyrotropin, was 5.2 (95% CI 2.1-8.7, P <.01). Conclusion A low serum thyrotropin concentration is associated with a >5-fold higher likelihood for the presence of atrial fibrillation with no significant difference between subclinical and overt hyperthyroidism. (Am Heart J 2001;142:838-42.)</description><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Comorbidity</subject><subject>Heart</subject><subject>Humans</subject><subject>Hyperthyroidism - blood</subject><subject>Hyperthyroidism - epidemiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAYwPEgipvTszfpRW_d8tYkPYrvMPCgnkOSJiyzLzNphX17M1rYyUMIgV8eHv4AXCO4RJDxVbPZLjGEaIlQSTg8AXMES54zTukpmEMIcS44JDNwEeM2PRkW7BzMEGKiQBzPwePHoE3tW29UnW32Oxv6zT50vvKxyVTMVBZ8_M6cMn0XMpeO6oNP1nkdfF2r3nftJThzqo72aroX4Ov56fPhNV-_v7w93K9zQ0nZ50RQqx2E2jpntCiLQuuSCYRUQQ12jCDKGUWVgZQVFhONHa4YFwo7UhBCyQLcjXN3ofsZbOxl46OxaYvWdkOUHGNSMM4SXI3QhC7GYJ3cBd-osJcIykM4mcLJQzg5hks_bqbRg25sdfRTqQRuJ6BiauWCao2PR0cRgUSQ5MrR2RTi19sgo_G2NbbywZpeVp3_d4k_dseI4w</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Auer, Johann</creator><creator>Scheibner, Peter</creator><creator>Mische, Thomas</creator><creator>Langsteger, Werner</creator><creator>Eber, Otto</creator><creator>Eber, Bernd</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Subclinical hyperthyroidism as a risk factor for atrial fibrillation</title><author>Auer, Johann ; Scheibner, Peter ; Mische, Thomas ; Langsteger, Werner ; Eber, Otto ; Eber, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-384ebf00beffcb8955bb96811a54c2f63147641dc0465e23b2f2d678a2f353343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Atrial Fibrillation - blood</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Comorbidity</topic><topic>Heart</topic><topic>Humans</topic><topic>Hyperthyroidism - blood</topic><topic>Hyperthyroidism - epidemiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auer, Johann</creatorcontrib><creatorcontrib>Scheibner, Peter</creatorcontrib><creatorcontrib>Mische, Thomas</creatorcontrib><creatorcontrib>Langsteger, Werner</creatorcontrib><creatorcontrib>Eber, Otto</creatorcontrib><creatorcontrib>Eber, Bernd</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auer, Johann</au><au>Scheibner, Peter</au><au>Mische, Thomas</au><au>Langsteger, Werner</au><au>Eber, Otto</au><au>Eber, Bernd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subclinical hyperthyroidism as a risk factor for atrial fibrillation</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>142</volume><issue>5</issue><spage>838</spage><epage>842</epage><pages>838-842</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Objectives Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically euthyroid persons is a risk factor for subsequent atrial fibrillation. Methods We studied 23,638 persons. The subjects were classified according to their serum thyrotropin concentrations: group 1 comprised those with normal values of serum thyrotropin concentration (>0.4-5.0 mU/L) and free tri-iodothyronine and free thyroxine concentrations were within the normal range (22,300 subjects), group 2 comprised those with both low serum thyrotropin values (≤0.03 mU/L) and elevated free tri-iodothyronine and free thyroxine concentrations (725 subjects), and group 3 comprised those with low values of serum thyrotropin (<0.4 mU/L) and free triiodothyronine and free thyroxine concentrations were within the normal range (613 subjects). Results Atrial fibrillation was present in 513 persons (2.3%) in group 1 with normal values for serum thyrotropin, 100 (13.8%) in group 2 with overt hyperthyroidism, and 78 (12.7%) in group 3 with subclinical hyperthyroidism. The prevalence of atrial fibrillation in patients with low serum thyrotropin concentrations (<0.4 mU/L) was 13.3% compared with 2.3% in patients with normal values for serum thyrotropin (P <.01). The relative risk of atrial fibrillation in subjects with low serum thyrotropin and normal free tri-iodothyronine and free thyroxine concentrations, compared with those with normal concentrations of serum thyrotropin, was 5.2 (95% CI 2.1-8.7, P <.01). Conclusion A low serum thyrotropin concentration is associated with a >5-fold higher likelihood for the presence of atrial fibrillation with no significant difference between subclinical and overt hyperthyroidism. (Am Heart J 2001;142:838-42.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>11685172</pmid><doi>10.1067/mhj.2001.119370</doi><tpages>5</tpages></addata></record> |
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| subjects | Atrial Fibrillation - blood Atrial Fibrillation - epidemiology Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Comorbidity Heart Humans Hyperthyroidism - blood Hyperthyroidism - epidemiology Medical sciences Middle Aged Risk Factors Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood |
| title | Subclinical hyperthyroidism as a risk factor for atrial fibrillation |
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