The Effect of Polyamine Homologation on the Transport and Cytotoxicity Properties of Polyamine−(DNA-Intercalator) Conjugates

An efficient five-step synthetic method was developed to access a homologous series of spermidine−acridine and spermidine−anthracene conjugates. The derivatives were comprised of a spermidine fragment covalently tethered at its N4 position to either an acridine or anthracene nucleus via an aliphatic...

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Veröffentlicht in:	Journal of organic chemistry 2000-09, Vol.65 (18), p.5590-5599
Hauptverfasser:	Phanstiel, Price, Harry L, Wang, Lu, Juusola, Jane, Kline, Martin, Shah, Sapna Majmundar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology DNA Topoisomerases, Type II - metabolism Drug Screening Assays, Antitumor Humans Intercalating Agents - chemistry Intercalating Agents - pharmacology Leukemia L1210 - pathology Magnetic Resonance Spectroscopy Mass Spectrometry Mice Polyamines - chemistry Polyamines - pharmacology Tumor Cells, Cultured
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