Urinary Deoxypyridinoline Excretion for the Evaluation of Bone Turnover in Chronic Renal Failure
Background: The urinary excretion of deoxypyridinoline (DPD) was evaluated in predialysis chronic renal failure (CRF), together with intact PTH and several classic markers of bone turnover in order to assess whether urine free and total DPD excretion are equivalent parameters of bone turnover in CRF...
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| Veröffentlicht in: | American journal of nephrology 2000-07, Vol.20 (4), p.283-290 |
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| creator | Coen, Giorgio Mantella, Daniela Calabria, Santo Sardella, Daniela Manni, Micaela Fassino, Valeria D’Anello, Emanuela Giustini, Marco Taggi, Franco |
| description | Background: The urinary excretion of deoxypyridinoline (DPD) was evaluated in predialysis chronic renal failure (CRF), together with intact PTH and several classic markers of bone turnover in order to assess whether urine free and total DPD excretion are equivalent parameters of bone turnover in CRF, and to evaluate the relationship between urine DPD excretion, PTH and the other bone markers. Methods: The study was carried out in 94 patients with different degrees of renal failure due to various kidney diseases. Besides urinary DPD expressed as free DPD, total DPD, free/total DPD, free DPD/Cr and total DPD/Cr, the following determinations were made: intact PTH, bone alkaline phosphatase (BALP), total alkaline phosphatase (AP), osteocalcin (BGP), serum C-terminal telopeptide of collagen type I (ICTP) and hydroxyproline (OHpro). The patients were divided into 3 groups according to the increasing severity of renal failure (Ccr >40, 40–20, 40 group, there was a parallel increase only in BGP and ICTP, parameters retained in the serum with decreasing renal function, while AP, BALP, total DPD and OHpro did not change. However, significant correlations between total DPD/Cr and PTH, BALP, BGP and ICTP were also found. Conclusions: In CRF free DPD is an unreliable index of bone turnover due to a probable interference in its production from the peptide-bound DPD. Total DPD or total DPD/Cr are better used. In spite of the significant correlations observed in advanced renal failure between PTH and most of the parameters examined, a resistance of bone tissue to PTH action in CRF must be considered. |
| doi_str_mv | 10.1159/000013602 |
| format | Article |
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Methods: The study was carried out in 94 patients with different degrees of renal failure due to various kidney diseases. Besides urinary DPD expressed as free DPD, total DPD, free/total DPD, free DPD/Cr and total DPD/Cr, the following determinations were made: intact PTH, bone alkaline phosphatase (BALP), total alkaline phosphatase (AP), osteocalcin (BGP), serum C-terminal telopeptide of collagen type I (ICTP) and hydroxyproline (OHpro). The patients were divided into 3 groups according to the increasing severity of renal failure (Ccr >40, 40–20, <20 ml/min). Results: The ratio free/total DPD decreased (NS) with advancing renal failure, and was inversely correlated with total DPD excretion. While PTH increased progressively to about four times the values observed in the Ccr >40 group, there was a parallel increase only in BGP and ICTP, parameters retained in the serum with decreasing renal function, while AP, BALP, total DPD and OHpro did not change. However, significant correlations between total DPD/Cr and PTH, BALP, BGP and ICTP were also found. Conclusions: In CRF free DPD is an unreliable index of bone turnover due to a probable interference in its production from the peptide-bound DPD. Total DPD or total DPD/Cr are better used. In spite of the significant correlations observed in advanced renal failure between PTH and most of the parameters examined, a resistance of bone tissue to PTH action in CRF must be considered.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000013602</identifier><identifier>PMID: 10970981</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Alkaline Phosphatase - metabolism ; Amino Acids - urine ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - urine ; Bone and Bones - enzymology ; Bone Remodeling ; Clinical Study ; Collagen ; Collagen Type I ; Creatinine - blood ; Creatinine - urine ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Humans ; Hydroxyproline - urine ; Intensive care medicine ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - urine ; Male ; Medical sciences ; Middle Aged ; Osteocalcin - blood ; Parathyroid Hormone - blood ; Peptides</subject><ispartof>American journal of nephrology, 2000-07, Vol.20 (4), p.283-290</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Jul/Aug 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-c480130fed924458c3b48bb434591980d4f23a47612bb143b3525b79450dcb143</citedby><cites>FETCH-LOGICAL-c415t-c480130fed924458c3b48bb434591980d4f23a47612bb143b3525b79450dcb143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1469505$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10970981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coen, Giorgio</creatorcontrib><creatorcontrib>Mantella, Daniela</creatorcontrib><creatorcontrib>Calabria, Santo</creatorcontrib><creatorcontrib>Sardella, Daniela</creatorcontrib><creatorcontrib>Manni, Micaela</creatorcontrib><creatorcontrib>Fassino, Valeria</creatorcontrib><creatorcontrib>D’Anello, Emanuela</creatorcontrib><creatorcontrib>Giustini, Marco</creatorcontrib><creatorcontrib>Taggi, Franco</creatorcontrib><title>Urinary Deoxypyridinoline Excretion for the Evaluation of Bone Turnover in Chronic Renal Failure</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>Background: The urinary excretion of deoxypyridinoline (DPD) was evaluated in predialysis chronic renal failure (CRF), together with intact PTH and several classic markers of bone turnover in order to assess whether urine free and total DPD excretion are equivalent parameters of bone turnover in CRF, and to evaluate the relationship between urine DPD excretion, PTH and the other bone markers. Methods: The study was carried out in 94 patients with different degrees of renal failure due to various kidney diseases. Besides urinary DPD expressed as free DPD, total DPD, free/total DPD, free DPD/Cr and total DPD/Cr, the following determinations were made: intact PTH, bone alkaline phosphatase (BALP), total alkaline phosphatase (AP), osteocalcin (BGP), serum C-terminal telopeptide of collagen type I (ICTP) and hydroxyproline (OHpro). The patients were divided into 3 groups according to the increasing severity of renal failure (Ccr >40, 40–20, <20 ml/min). Results: The ratio free/total DPD decreased (NS) with advancing renal failure, and was inversely correlated with total DPD excretion. While PTH increased progressively to about four times the values observed in the Ccr >40 group, there was a parallel increase only in BGP and ICTP, parameters retained in the serum with decreasing renal function, while AP, BALP, total DPD and OHpro did not change. However, significant correlations between total DPD/Cr and PTH, BALP, BGP and ICTP were also found. Conclusions: In CRF free DPD is an unreliable index of bone turnover due to a probable interference in its production from the peptide-bound DPD. Total DPD or total DPD/Cr are better used. In spite of the significant correlations observed in advanced renal failure between PTH and most of the parameters examined, a resistance of bone tissue to PTH action in CRF must be considered.</description><subject>Aged</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Amino Acids - urine</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Bone and Bones - enzymology</subject><subject>Bone Remodeling</subject><subject>Clinical Study</subject><subject>Collagen</subject><subject>Collagen Type I</subject><subject>Creatinine - blood</subject><subject>Creatinine - urine</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxyproline - urine</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteocalcin - blood</subject><subject>Parathyroid Hormone - blood</subject><subject>Peptides</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0d1LHDEQAPAgLXpaH_pcKEGk0Ierk6_dzaM9tSpSQfR5zWazGruXXJNb8f57R-9QkULzkMDMjxkmQ8hnBj8YU3oP8DBRAF8jIyY5G-uihA9kBFzBuAKtNshmzneIeAXlOtlgoEvQFRuR66vkg0kLeuDiw2K2SL71IfY-OHr4YJOb-xhoFxOd32Lk3vSDeQ7Fjv6MiC6HFOK9S9QHOrlNMXhLL1wwPT0yvh-S-0Q-dqbPbnv1bpGro8PLyfH47PzXyWT_bGwlU3O8KxwBOtdqLqWqrGhk1TRSSKWZrqCVHRdGlgXjTcOkaITiqim1VNDap8AW-basO0vx7-DyvJ76bF3fm-DikOuSc4GF_w85aNBIEe68g3cRp8Uhai4KLQtdFoi-L5FNMefkunqW_BQ_tGZQPy2nflkO2q-rgkMzde0budwGgt0VMNmavksmWJ9fHbZUoJB9WbI_Jt249Jpfddn5Z3b_9PczqGdtJx4Bn_Socg</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Coen, Giorgio</creator><creator>Mantella, Daniela</creator><creator>Calabria, Santo</creator><creator>Sardella, Daniela</creator><creator>Manni, Micaela</creator><creator>Fassino, Valeria</creator><creator>D’Anello, Emanuela</creator><creator>Giustini, Marco</creator><creator>Taggi, Franco</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Urinary Deoxypyridinoline Excretion for the Evaluation of Bone Turnover in Chronic Renal Failure</title><author>Coen, Giorgio ; Mantella, Daniela ; Calabria, Santo ; Sardella, Daniela ; Manni, Micaela ; Fassino, Valeria ; D’Anello, Emanuela ; Giustini, Marco ; Taggi, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-c480130fed924458c3b48bb434591980d4f23a47612bb143b3525b79450dcb143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Amino Acids - urine</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Bone and Bones - enzymology</topic><topic>Bone Remodeling</topic><topic>Clinical Study</topic><topic>Collagen</topic><topic>Collagen Type I</topic><topic>Creatinine - blood</topic><topic>Creatinine - urine</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxyproline - urine</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteocalcin - blood</topic><topic>Parathyroid Hormone - blood</topic><topic>Peptides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coen, Giorgio</creatorcontrib><creatorcontrib>Mantella, Daniela</creatorcontrib><creatorcontrib>Calabria, Santo</creatorcontrib><creatorcontrib>Sardella, Daniela</creatorcontrib><creatorcontrib>Manni, Micaela</creatorcontrib><creatorcontrib>Fassino, Valeria</creatorcontrib><creatorcontrib>D’Anello, Emanuela</creatorcontrib><creatorcontrib>Giustini, Marco</creatorcontrib><creatorcontrib>Taggi, Franco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coen, Giorgio</au><au>Mantella, Daniela</au><au>Calabria, Santo</au><au>Sardella, Daniela</au><au>Manni, Micaela</au><au>Fassino, Valeria</au><au>D’Anello, Emanuela</au><au>Giustini, Marco</au><au>Taggi, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Deoxypyridinoline Excretion for the Evaluation of Bone Turnover in Chronic Renal Failure</atitle><jtitle>American journal of nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>20</volume><issue>4</issue><spage>283</spage><epage>290</epage><pages>283-290</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><coden>AJNED9</coden><abstract>Background: The urinary excretion of deoxypyridinoline (DPD) was evaluated in predialysis chronic renal failure (CRF), together with intact PTH and several classic markers of bone turnover in order to assess whether urine free and total DPD excretion are equivalent parameters of bone turnover in CRF, and to evaluate the relationship between urine DPD excretion, PTH and the other bone markers. Methods: The study was carried out in 94 patients with different degrees of renal failure due to various kidney diseases. Besides urinary DPD expressed as free DPD, total DPD, free/total DPD, free DPD/Cr and total DPD/Cr, the following determinations were made: intact PTH, bone alkaline phosphatase (BALP), total alkaline phosphatase (AP), osteocalcin (BGP), serum C-terminal telopeptide of collagen type I (ICTP) and hydroxyproline (OHpro). The patients were divided into 3 groups according to the increasing severity of renal failure (Ccr >40, 40–20, <20 ml/min). Results: The ratio free/total DPD decreased (NS) with advancing renal failure, and was inversely correlated with total DPD excretion. While PTH increased progressively to about four times the values observed in the Ccr >40 group, there was a parallel increase only in BGP and ICTP, parameters retained in the serum with decreasing renal function, while AP, BALP, total DPD and OHpro did not change. However, significant correlations between total DPD/Cr and PTH, BALP, BGP and ICTP were also found. Conclusions: In CRF free DPD is an unreliable index of bone turnover due to a probable interference in its production from the peptide-bound DPD. Total DPD or total DPD/Cr are better used. In spite of the significant correlations observed in advanced renal failure between PTH and most of the parameters examined, a resistance of bone tissue to PTH action in CRF must be considered.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10970981</pmid><doi>10.1159/000013602</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Alkaline Phosphatase - metabolism Amino Acids - urine Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - blood Biomarkers - urine Bone and Bones - enzymology Bone Remodeling Clinical Study Collagen Collagen Type I Creatinine - blood Creatinine - urine Emergency and intensive care: renal failure. Dialysis management Female Humans Hydroxyproline - urine Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - urine Male Medical sciences Middle Aged Osteocalcin - blood Parathyroid Hormone - blood Peptides |
| title | Urinary Deoxypyridinoline Excretion for the Evaluation of Bone Turnover in Chronic Renal Failure |
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