Targeted Delivery of Anti-CTLA-4 Antibody Downregulates T Cell Function in Vitro and in Vivo

CTLA-4 is a T cell surface molecule that binds to the costimulatory molecules CD80 and CD86 on antigen-presenting cells and downregulates T cell function. Therefore, we wanted to test whether antigen-specific activated T cells could be inhibited through directed CTLA-4 signaling using a bispecific a...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2001-11, Vol.101 (2), p.136-145
Hauptverfasser:	Rao, Seema, Vasu, Chenthamarakshan, Martinez, Osvaldo, Kaithamana, Shashi, Prabhakar, Bellur S., Holterman, Mark J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals antibodies Antibodies, Bispecific - pharmacology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigens, CD Antigens, Differentiation - immunology Autoimmune Diseases - therapy Biological and medical sciences costimulatory molecules Cricetinae CTLA-4 Antigen CTLA-4 protein Down-Regulation Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunoconjugates Immunological tolerance Immunosuppressive Agents - pharmacology immunotherapy Interleukin-2 - biosynthesis Mice Mice, Inbred BALB C Mice, Inbred CBA Organ Specificity Receptors, Thyrotropin - immunology T-Lymphocytes - immunology thyroid-stimulating hormone receptors tolerance/suppression
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