Grading choroidal neovascular membrane regression after strontium plaque radiotherapy; masked subjective evaluation vs planimetry
To analyze angiographic changes in choroidal neovascular membranes (CNVM) after strontium-plaque (90Sr) irradiation for exudative age-related macular degeneration (AMD) using masked measurement of the CNVM areas and a masked subjective comparison of CNVM size and leakage. We studied the baseline, 3,...
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| Veröffentlicht in: | European journal of ophthalmology 2001-07, Vol.11 (3), p.269-276 |
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| creator | JAAKKOLA, A TOMMILA, P LAATIKAINEN, L IMMONEN, I |
| description | To analyze angiographic changes in choroidal neovascular membranes (CNVM) after strontium-plaque (90Sr) irradiation for exudative age-related macular degeneration (AMD) using masked measurement of the CNVM areas and a masked subjective comparison of CNVM size and leakage.
We studied the baseline, 3, 6, and 12-month angiograms of 19 eyes treated with 90Sr-plaque irradiation for exudative AMD. The area of CNVM-related hyperfluorescence was measured quantitatively, and the angiograms were subjectively evaluated by a masked grader.
In 7 of the 19 eyes the CNVM-related hyperfluorescence was too scattered to be analyzed by planimetry but masked subjective grading correlated with the clinical response to irradiation. In the remaining 12 eyes, the CNVM decreased in size in 67% of the eyes and showed leakage in 67%. Planimetry and subjective assessment of the size and leakage of the CNVMs similarly reflected the regression after irradiation.
CNVM size and leakage frequently diminish after 90Sr-plaque irradiation. Quantitative measurement of the CNVM areas, or a grading system based on masked subjective assessment, give similar results for evaluating these changes. Masked subjective grading can be used even in cases where the CNVM is too scattered to be outlined for planimetry. |
| doi_str_mv | 10.1177/112067210101100310 |
| format | Article |
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We studied the baseline, 3, 6, and 12-month angiograms of 19 eyes treated with 90Sr-plaque irradiation for exudative AMD. The area of CNVM-related hyperfluorescence was measured quantitatively, and the angiograms were subjectively evaluated by a masked grader.
In 7 of the 19 eyes the CNVM-related hyperfluorescence was too scattered to be analyzed by planimetry but masked subjective grading correlated with the clinical response to irradiation. In the remaining 12 eyes, the CNVM decreased in size in 67% of the eyes and showed leakage in 67%. Planimetry and subjective assessment of the size and leakage of the CNVMs similarly reflected the regression after irradiation.
CNVM size and leakage frequently diminish after 90Sr-plaque irradiation. Quantitative measurement of the CNVM areas, or a grading system based on masked subjective assessment, give similar results for evaluating these changes. Masked subjective grading can be used even in cases where the CNVM is too scattered to be outlined for planimetry.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/112067210101100310</identifier><identifier>PMID: 11681507</identifier><language>eng</language><publisher>Milano: Wichtig</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Brachytherapy - methods ; Choroidal Neovascularization - diagnosis ; Choroidal Neovascularization - radiotherapy ; Diseases of the eye ; Double-Blind Method ; Female ; Fluorescein Angiography ; Humans ; Macular Degeneration - diagnosis ; Macular Degeneration - radiotherapy ; Male ; Medical sciences ; Middle Aged ; Pilot Projects ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Strontium Radioisotopes - therapeutic use</subject><ispartof>European journal of ophthalmology, 2001-07, Vol.11 (3), p.269-276</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-27a6f531a008de4669ba343877cc66c34041f53847e6957a89036849dc2c08593</citedby><cites>FETCH-LOGICAL-c329t-27a6f531a008de4669ba343877cc66c34041f53847e6957a89036849dc2c08593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14072009$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11681507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JAAKKOLA, A</creatorcontrib><creatorcontrib>TOMMILA, P</creatorcontrib><creatorcontrib>LAATIKAINEN, L</creatorcontrib><creatorcontrib>IMMONEN, I</creatorcontrib><title>Grading choroidal neovascular membrane regression after strontium plaque radiotherapy; masked subjective evaluation vs planimetry</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>To analyze angiographic changes in choroidal neovascular membranes (CNVM) after strontium-plaque (90Sr) irradiation for exudative age-related macular degeneration (AMD) using masked measurement of the CNVM areas and a masked subjective comparison of CNVM size and leakage.
We studied the baseline, 3, 6, and 12-month angiograms of 19 eyes treated with 90Sr-plaque irradiation for exudative AMD. The area of CNVM-related hyperfluorescence was measured quantitatively, and the angiograms were subjectively evaluated by a masked grader.
In 7 of the 19 eyes the CNVM-related hyperfluorescence was too scattered to be analyzed by planimetry but masked subjective grading correlated with the clinical response to irradiation. In the remaining 12 eyes, the CNVM decreased in size in 67% of the eyes and showed leakage in 67%. Planimetry and subjective assessment of the size and leakage of the CNVMs similarly reflected the regression after irradiation.
CNVM size and leakage frequently diminish after 90Sr-plaque irradiation. Quantitative measurement of the CNVM areas, or a grading system based on masked subjective assessment, give similar results for evaluating these changes. Masked subjective grading can be used even in cases where the CNVM is too scattered to be outlined for planimetry.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brachytherapy - methods</subject><subject>Choroidal Neovascularization - diagnosis</subject><subject>Choroidal Neovascularization - radiotherapy</subject><subject>Diseases of the eye</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Macular Degeneration - diagnosis</subject><subject>Macular Degeneration - radiotherapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Strontium Radioisotopes - therapeutic use</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1P3DAQhq2qqHy0f6AH5Et7C4w_YifiVCEKSEhc4BzNOhMwJPFiOyvtkX9er1iJQzUHj-TnfTV6GPsp4EwIa8-FkGCsFFBGACgBX9iRsFJXBoT5WvYCVDvikB2n9AIgodXyGzsUwjSiBnvE3q8j9n5-4u45xOB7HPlMYYPJLSNGPtG0ijgTj_QUKSUfZo5DpshTjmHOfpn4esS3pRClJ-RnirjeXvAJ0yv1PC2rF3LZb4jTBscF865hk3ah2U-U4_Y7OxhwTPRj_56wx79XD5c31d399e3ln7vKKdnmSlo0Q60EAjQ9aWPaFSqtGmudM8YpDVqU_0ZbMm1tsWlBmUa3vZMOmrpVJ-z3R-86hnJvyt3kk6OxHEJhSZ2VUkkr6gLKD9DFkFKkoVtHP2HcdgK6nfjuf_EldLpvX1YT9Z-RvekC_NoDxS2OQ7HqfPrkNFgJ0Kp_lBWMkA</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>JAAKKOLA, A</creator><creator>TOMMILA, P</creator><creator>LAATIKAINEN, L</creator><creator>IMMONEN, I</creator><general>Wichtig</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Grading choroidal neovascular membrane regression after strontium plaque radiotherapy; masked subjective evaluation vs planimetry</title><author>JAAKKOLA, A ; TOMMILA, P ; LAATIKAINEN, L ; IMMONEN, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-27a6f531a008de4669ba343877cc66c34041f53847e6957a89036849dc2c08593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brachytherapy - methods</topic><topic>Choroidal Neovascularization - diagnosis</topic><topic>Choroidal Neovascularization - radiotherapy</topic><topic>Diseases of the eye</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Macular Degeneration - diagnosis</topic><topic>Macular Degeneration - radiotherapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Strontium Radioisotopes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JAAKKOLA, A</creatorcontrib><creatorcontrib>TOMMILA, P</creatorcontrib><creatorcontrib>LAATIKAINEN, L</creatorcontrib><creatorcontrib>IMMONEN, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JAAKKOLA, A</au><au>TOMMILA, P</au><au>LAATIKAINEN, L</au><au>IMMONEN, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grading choroidal neovascular membrane regression after strontium plaque radiotherapy; masked subjective evaluation vs planimetry</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>11</volume><issue>3</issue><spage>269</spage><epage>276</epage><pages>269-276</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>To analyze angiographic changes in choroidal neovascular membranes (CNVM) after strontium-plaque (90Sr) irradiation for exudative age-related macular degeneration (AMD) using masked measurement of the CNVM areas and a masked subjective comparison of CNVM size and leakage.
We studied the baseline, 3, 6, and 12-month angiograms of 19 eyes treated with 90Sr-plaque irradiation for exudative AMD. The area of CNVM-related hyperfluorescence was measured quantitatively, and the angiograms were subjectively evaluated by a masked grader.
In 7 of the 19 eyes the CNVM-related hyperfluorescence was too scattered to be analyzed by planimetry but masked subjective grading correlated with the clinical response to irradiation. In the remaining 12 eyes, the CNVM decreased in size in 67% of the eyes and showed leakage in 67%. Planimetry and subjective assessment of the size and leakage of the CNVMs similarly reflected the regression after irradiation.
CNVM size and leakage frequently diminish after 90Sr-plaque irradiation. Quantitative measurement of the CNVM areas, or a grading system based on masked subjective assessment, give similar results for evaluating these changes. Masked subjective grading can be used even in cases where the CNVM is too scattered to be outlined for planimetry.</abstract><cop>Milano</cop><pub>Wichtig</pub><pmid>11681507</pmid><doi>10.1177/112067210101100310</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Brachytherapy - methods Choroidal Neovascularization - diagnosis Choroidal Neovascularization - radiotherapy Diseases of the eye Double-Blind Method Female Fluorescein Angiography Humans Macular Degeneration - diagnosis Macular Degeneration - radiotherapy Male Medical sciences Middle Aged Pilot Projects Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Strontium Radioisotopes - therapeutic use |
| title | Grading choroidal neovascular membrane regression after strontium plaque radiotherapy; masked subjective evaluation vs planimetry |
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