In-vivo particle mediated delivery of mRNA to mammalian tissues: ballistic and biologic effects

Biolistic transmission of mRNA provides transient gene therapy to in vivo organs. This study documents particle mediated mRNA transmission to a solid organ and wound healing model using the mRNA of Green Fluorescent Protein to determine optimal delivery parameters. Renal function, bullet penetration...

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Veröffentlicht in:	Wound repair and regeneration 2001-07, Vol.9 (4), p.287-296
Hauptverfasser:	Sohn, Richard L., Murray, Mary T., Schwarz, Karl, Nyitray, Joseph, Purray, Praveen, Franko, Alexander P., Palmer, Kenneth C., Diebel, Lawrence N., Dulchavsky, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Availability Disease Models, Animal Drug Delivery Systems Epidermal Growth Factor - pharmacology Gene Transfer Techniques Genetic Therapy - methods Green Fluorescent Proteins Humans Immunohistochemistry Kidney - physiology Luminescent Proteins Male Rats Rats, Sprague-Dawley Regeneration RNA, Messenger - pharmacology Sensitivity and Specificity Wound Healing - physiology Wounds and Injuries - genetics Wounds and Injuries - pathology Wounds and Injuries - therapy
Online-Zugang:	Volltext
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