Effects of Reverse-Transcriptase Mutations M184V and E89G on Simian Immunodeficiency Virus in Rhesus Monkeys

Mutations in human immunodeficiency virus type 1 reverse-transcriptase codons 89 and 184 confer inhibitor resistance and alter the mutation spectrum of the enzyme. Six macaques were inoculated with wild-type or mutated derivatives (E89G or E89G and M184V) of simian immunodeficiency virus macaque (SI...

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Veröffentlicht in:	The Journal of infectious diseases 2001-11, Vol.184 (10), p.1262-1267
Hauptverfasser:	Newstein, Michael C., Desrosiers, Ronald C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cell Line Cell lines Codon Genetic mutation HIV HIV 1 Human immunodeficiency virus 1 Human viral diseases Infections Infectious diseases Inoculation Lymphocytes Macaca mulatta Major Articles Medical sciences Mutation Pharmacology. Drug treatments RNA RNA-Directed DNA Polymerase - genetics Sequence Analysis Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - physiology Time Factors Transfection Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virus Replication - genetics Viruses
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