Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

Astrocytomas are the leading cause of brain cancer in humans. Because these tumours are highly infiltrative, current treatments that rely on targeting the tumour mass are often ineffective. A mouse model for astrocytoma would be a powerful tool for dissecting tumour progression and testing therapeut...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2000-09, Vol.26 (1), p.109-113
Hauptverfasser:	Reilly, Karlyne M., Loisel, Dagan A., Bronson, Roderick T., McLaughlin, Margaret E., Jacks, Tyler
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Agriculture Alleles Animal Genetics and Genomics Animals astrocytoma Astrocytoma - genetics Astrocytoma - pathology Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - secondary Brain tumors Cancer Research Cerebellum - pathology Classical genetics, quantitative genetics, hybrids Complications and side effects Culture Techniques Diagnosis Female Fundamental and applied biological sciences. Psychology Gene Function Gene mutations Genes, Neurofibromatosis 1 - genetics Genes, p53 - genetics Genetic screening Genetics Genetics of eukaryotes. Biological and molecular evolution Genotype glioblastoma Glioblastoma - genetics Glioblastoma - pathology Glioblastoma - secondary Glioblastoma multiforme Health aspects Human Genetics Humans Immunohistochemistry letter Male Methods Mice Mice, Mutant Strains Mice, Nude Mutation Necrosis Neoplasm Transplantation Nerve Tissue Proteins - biosynthesis Neurofibromin 1 Nf1 gene Pituitary Gland - pathology Polymerase Chain Reaction Risk factors Species Specificity Tumor Suppressor Protein p53 - biosynthesis Tumors Vertebrata
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!