Locally advanced breast carcinoma: computer assisted semiquantitative analysis of color Doppler ultrasonography in the evaluation of tumor response to neoadjuvant chemotherapy (work in progress)
We aimed to evaluate objectively the value of color Doppler flow imaging in the assessment of response of locally advanced breast cancer to primary medical treatment by using a computer assisted semiquantitative method. Prior to and after neoadjuvant treatment, 17 patients with locally advanced brea...
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| Veröffentlicht in: | Journal of ultrasound in medicine 2000-09, Vol.19 (9), p.601-607 |
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| creator | Huber, S Medl, M Helbich, T Taucher, S Wagner, T Rudas, M Zuna, I Delorme, S |
| description | We aimed to evaluate objectively the value of color Doppler flow imaging in the assessment of response of locally advanced breast cancer to primary medical treatment by using a computer assisted semiquantitative method. Prior to and after neoadjuvant treatment, 17 patients with locally advanced breast carcinoma were prospectively evaluated by physical examination and computer assisted semiquantitative color Doppler ultrasonography. The results of clinical and color Doppler examination were finally correlated to the histopathologic evaluation of tumor response. The degree of concordance between posttherapeutic histopathologic results, clinical examination, and color Doppler assessment was evaluated by kappa statistics. Concordance was 0.474 (0.135‐0.813) between histopathologic results and clinical posttherapeutic assessment and 0.870 (0.627‐1.113) between histopathologic results and semiquantitative color Doppler examination. Objective semiquantitative assessment of tumor vascularity as displayed by color Doppler ultrasonography has potential as a functional tool for measuring tumor response to neoadjuvant chemotherapy. |
| doi_str_mv | 10.7863/jum.2000.19.9.601 |
| format | Article |
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Prior to and after neoadjuvant treatment, 17 patients with locally advanced breast carcinoma were prospectively evaluated by physical examination and computer assisted semiquantitative color Doppler ultrasonography. The results of clinical and color Doppler examination were finally correlated to the histopathologic evaluation of tumor response. The degree of concordance between posttherapeutic histopathologic results, clinical examination, and color Doppler assessment was evaluated by kappa statistics. Concordance was 0.474 (0.135‐0.813) between histopathologic results and clinical posttherapeutic assessment and 0.870 (0.627‐1.113) between histopathologic results and semiquantitative color Doppler examination. Objective semiquantitative assessment of tumor vascularity as displayed by color Doppler ultrasonography has potential as a functional tool for measuring tumor response to neoadjuvant chemotherapy.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.7863/jum.2000.19.9.601</identifier><identifier>PMID: 10972556</identifier><identifier>CODEN: JUMEDA</identifier><language>eng</language><publisher>Laurel, MD: Am inst Ulrrasound Med</publisher><subject>Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Carcinoma - diagnostic imaging ; Carcinoma - drug therapy ; Carcinoma - pathology ; Female ; Genital system. Mammary gland ; Gynecology. Andrology. 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Prior to and after neoadjuvant treatment, 17 patients with locally advanced breast carcinoma were prospectively evaluated by physical examination and computer assisted semiquantitative color Doppler ultrasonography. The results of clinical and color Doppler examination were finally correlated to the histopathologic evaluation of tumor response. The degree of concordance between posttherapeutic histopathologic results, clinical examination, and color Doppler assessment was evaluated by kappa statistics. Concordance was 0.474 (0.135‐0.813) between histopathologic results and clinical posttherapeutic assessment and 0.870 (0.627‐1.113) between histopathologic results and semiquantitative color Doppler examination. Objective semiquantitative assessment of tumor vascularity as displayed by color Doppler ultrasonography has potential as a functional tool for measuring tumor response to neoadjuvant chemotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - drug therapy</subject><subject>Carcinoma - pathology</subject><subject>Female</subject><subject>Genital system. Mammary gland</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Tumors</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Doppler, Color</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-P1CAchonRuOvoB_BiOKjRw4xAh1I2Xsz6P2O8uGfCULrDSEsX6DT9en4yf00n6s0TSXmelzd5i9BTSjaiKos3x6HdMELIhsqN3JSE3kOXlHOyliUt7qNLwkS13jIpLtCjlI6EMELF9iG6oEQKxnl5iX7tgtHeT1jXJ90ZW-N9tDplbHQ0rgutvsImtP2QbcQ6JZcyMMm27m7QXXZZZ3eyWHfaT3CJQwO4DxG_D33vwRl8jjqFLtxG3R8m7DqcDxbbk_YDuKGblTy0oESb-tAli3PAnQ26Pg7QCaocbBtAgoAJvxpD_Dmn9BEibUqvH6MHjfbJPjmfK3Tz8cOP68_r3fdPX67f7daG04quac32hS23XBS8aCwzRja0MQVnmrKiKNmeCyMqKbdMW9MUVO6rhte0pEISpnmxQi-XXHj5brApq9YlY73XUHZISjDGKgZZK0QX0MSQUrSN6qNrdZwUJWoeTsFwah5OUamkguHAeXYOH_atrf8xlqUAeH4GdILFmghrufSX2wpByFzy7YKNztvp_w-rrzff5g9UyqXGi0U_uNvD6KJVqYXfA0pRNY7jn7q_ATv1xkc</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>Huber, S</creator><creator>Medl, M</creator><creator>Helbich, T</creator><creator>Taucher, S</creator><creator>Wagner, T</creator><creator>Rudas, M</creator><creator>Zuna, I</creator><creator>Delorme, S</creator><general>Am inst Ulrrasound Med</general><general>American Institute of Ultrasound in Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200009</creationdate><title>Locally advanced breast carcinoma: computer assisted semiquantitative analysis of color Doppler ultrasonography in the evaluation of tumor response to neoadjuvant chemotherapy (work in progress)</title><author>Huber, S ; Medl, M ; Helbich, T ; Taucher, S ; Wagner, T ; Rudas, M ; Zuna, I ; Delorme, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5181-1d2b3e6457353fe2cc9f1fc352a123362b57c789942aecf319b8f5d1617902a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - drug therapy</topic><topic>Carcinoma - pathology</topic><topic>Female</topic><topic>Genital system. Mammary gland</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy</topic><topic>Tumors</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography, Doppler, Color</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huber, S</creatorcontrib><creatorcontrib>Medl, M</creatorcontrib><creatorcontrib>Helbich, T</creatorcontrib><creatorcontrib>Taucher, S</creatorcontrib><creatorcontrib>Wagner, T</creatorcontrib><creatorcontrib>Rudas, M</creatorcontrib><creatorcontrib>Zuna, I</creatorcontrib><creatorcontrib>Delorme, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huber, S</au><au>Medl, M</au><au>Helbich, T</au><au>Taucher, S</au><au>Wagner, T</au><au>Rudas, M</au><au>Zuna, I</au><au>Delorme, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Locally advanced breast carcinoma: computer assisted semiquantitative analysis of color Doppler ultrasonography in the evaluation of tumor response to neoadjuvant chemotherapy (work in progress)</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>2000-09</date><risdate>2000</risdate><volume>19</volume><issue>9</issue><spage>601</spage><epage>607</epage><pages>601-607</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><coden>JUMEDA</coden><abstract>We aimed to evaluate objectively the value of color Doppler flow imaging in the assessment of response of locally advanced breast cancer to primary medical treatment by using a computer assisted semiquantitative method. Prior to and after neoadjuvant treatment, 17 patients with locally advanced breast carcinoma were prospectively evaluated by physical examination and computer assisted semiquantitative color Doppler ultrasonography. The results of clinical and color Doppler examination were finally correlated to the histopathologic evaluation of tumor response. The degree of concordance between posttherapeutic histopathologic results, clinical examination, and color Doppler assessment was evaluated by kappa statistics. Concordance was 0.474 (0.135‐0.813) between histopathologic results and clinical posttherapeutic assessment and 0.870 (0.627‐1.113) between histopathologic results and semiquantitative color Doppler examination. 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| subjects | Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast Neoplasms - diagnostic imaging Breast Neoplasms - drug therapy Breast Neoplasms - pathology Carcinoma - diagnostic imaging Carcinoma - drug therapy Carcinoma - pathology Female Genital system. Mammary gland Gynecology. Andrology. Obstetrics Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Mammary gland diseases Medical sciences Middle Aged Neoadjuvant Therapy Tumors Ultrasonic investigative techniques Ultrasonography, Doppler, Color |
| title | Locally advanced breast carcinoma: computer assisted semiquantitative analysis of color Doppler ultrasonography in the evaluation of tumor response to neoadjuvant chemotherapy (work in progress) |
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