A qualitative test of the balloon model for BOLD-based MR signal changes at 3T
The aim of this study was to adapt the balloon model for BOLD‐based MR signal changes to a magnetic field strength of 3T and to examine its validity. The simultaneous measurement of BOLD and diffusion‐weighted BOLD responses was performed. The amplitude of the BOLD peak was found to be similar for a...
Gespeichert in:
| Veröffentlicht in: | Magnetic resonance in medicine 2001-11, Vol.46 (5), p.891-899 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 899 |
|---|---|
| container_issue | 5 |
| container_start_page | 891 |
| container_title | Magnetic resonance in medicine |
| container_volume | 46 |
| creator | Mildner, Toralf Norris, David G. Schwarzbauer, Christian Wiggins, Christopher J. |
| description | The aim of this study was to adapt the balloon model for BOLD‐based MR signal changes to a magnetic field strength of 3T and to examine its validity. The simultaneous measurement of BOLD and diffusion‐weighted BOLD responses was performed. The amplitude of the BOLD peak was found to be similar for all subjects when a short visual stimulus of 6 sec was used. The rise‐time to the BOLD peak and the shape and depth of the poststimulus undershoot varied significantly. A fit of the experimental BOLD responses was found to be possible by use of parameters within a reasonable physiological range. The relations between these parameters and their influence on the modeled BOLD responses is discussed. A prediction of the balloon model is the occurrence of a BOLD overshoot, i.e., a lag between the changes of the blood volume and the blood flow after the start of the stimulation. Experimental evidence for the existence of a BOLD overshoot is presented. Magn Reson Med 46:891–899, 2001. © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.1274 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72225944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72225944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4004-f5af1ec638d9e65e86279a22129494b48855896ee64d91604553eeebb7cc09423</originalsourceid><addsrcrecordid>eNp10MlO5DAQgGELMYJmkXgC5AuIS8B2vMRH9kXdDWpAHC3HqUDAScBOM8Pbk1ZHw4lTXT5VlX6Edig5pISwozrUh5QpvoJGVDCWMKH5KhoRxUmSUs3X0UaMr4QQrRVfQ-uUSiUkJyM0PcYfc-urznbVJ-AOYofbEncvgHPrfds2uG4L8LhsAz65HZ8luY1Q4MkMx-q5sR67F9s8Q8S2w-nDFvpTWh9he5ib6PHi_OH0KhnfXl6fHo8TxwnhSSlsScHJNCs0SAGZZEpbxijTXPOcZ5kQmZYAkheaSsKFSAEgz5VzRHOWbqL95d730H7M-6dNXUUH3tsG2nk0irFFA97DgyV0oY0xQGneQ1Xb8GUoMYt2pm9nFu16ujvsnOc1FD9wiNWDvQHY6Kwvg21cFX8cp0QRQXuXLN3fysPXrwfNZDYZDg--ih38--9teDNSpUqYp-mlmU3vb06u7s7MTfoNUiWRYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72225944</pqid></control><display><type>article</type><title>A qualitative test of the balloon model for BOLD-based MR signal changes at 3T</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Mildner, Toralf ; Norris, David G. ; Schwarzbauer, Christian ; Wiggins, Christopher J.</creator><creatorcontrib>Mildner, Toralf ; Norris, David G. ; Schwarzbauer, Christian ; Wiggins, Christopher J.</creatorcontrib><description>The aim of this study was to adapt the balloon model for BOLD‐based MR signal changes to a magnetic field strength of 3T and to examine its validity. The simultaneous measurement of BOLD and diffusion‐weighted BOLD responses was performed. The amplitude of the BOLD peak was found to be similar for all subjects when a short visual stimulus of 6 sec was used. The rise‐time to the BOLD peak and the shape and depth of the poststimulus undershoot varied significantly. A fit of the experimental BOLD responses was found to be possible by use of parameters within a reasonable physiological range. The relations between these parameters and their influence on the modeled BOLD responses is discussed. A prediction of the balloon model is the occurrence of a BOLD overshoot, i.e., a lag between the changes of the blood volume and the blood flow after the start of the stimulation. Experimental evidence for the existence of a BOLD overshoot is presented. Magn Reson Med 46:891–899, 2001. © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1274</identifier><identifier>PMID: 11675640</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>3Tesla ; balloon model ; Biological and medical sciences ; BOLD response ; Brain - metabolism ; Brain - physiology ; diffusion weighting ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Medical sciences ; Nervous system ; Photic Stimulation ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>Magnetic resonance in medicine, 2001-11, Vol.46 (5), p.891-899</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4004-f5af1ec638d9e65e86279a22129494b48855896ee64d91604553eeebb7cc09423</citedby><cites>FETCH-LOGICAL-c4004-f5af1ec638d9e65e86279a22129494b48855896ee64d91604553eeebb7cc09423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1274$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1274$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14107051$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11675640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mildner, Toralf</creatorcontrib><creatorcontrib>Norris, David G.</creatorcontrib><creatorcontrib>Schwarzbauer, Christian</creatorcontrib><creatorcontrib>Wiggins, Christopher J.</creatorcontrib><title>A qualitative test of the balloon model for BOLD-based MR signal changes at 3T</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>The aim of this study was to adapt the balloon model for BOLD‐based MR signal changes to a magnetic field strength of 3T and to examine its validity. The simultaneous measurement of BOLD and diffusion‐weighted BOLD responses was performed. The amplitude of the BOLD peak was found to be similar for all subjects when a short visual stimulus of 6 sec was used. The rise‐time to the BOLD peak and the shape and depth of the poststimulus undershoot varied significantly. A fit of the experimental BOLD responses was found to be possible by use of parameters within a reasonable physiological range. The relations between these parameters and their influence on the modeled BOLD responses is discussed. A prediction of the balloon model is the occurrence of a BOLD overshoot, i.e., a lag between the changes of the blood volume and the blood flow after the start of the stimulation. Experimental evidence for the existence of a BOLD overshoot is presented. Magn Reson Med 46:891–899, 2001. © 2001 Wiley‐Liss, Inc.</description><subject>3Tesla</subject><subject>balloon model</subject><subject>Biological and medical sciences</subject><subject>BOLD response</subject><subject>Brain - metabolism</subject><subject>Brain - physiology</subject><subject>diffusion weighting</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Photic Stimulation</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MlO5DAQgGELMYJmkXgC5AuIS8B2vMRH9kXdDWpAHC3HqUDAScBOM8Pbk1ZHw4lTXT5VlX6Edig5pISwozrUh5QpvoJGVDCWMKH5KhoRxUmSUs3X0UaMr4QQrRVfQ-uUSiUkJyM0PcYfc-urznbVJ-AOYofbEncvgHPrfds2uG4L8LhsAz65HZ8luY1Q4MkMx-q5sR67F9s8Q8S2w-nDFvpTWh9he5ib6PHi_OH0KhnfXl6fHo8TxwnhSSlsScHJNCs0SAGZZEpbxijTXPOcZ5kQmZYAkheaSsKFSAEgz5VzRHOWbqL95d730H7M-6dNXUUH3tsG2nk0irFFA97DgyV0oY0xQGneQ1Xb8GUoMYt2pm9nFu16ujvsnOc1FD9wiNWDvQHY6Kwvg21cFX8cp0QRQXuXLN3fysPXrwfNZDYZDg--ih38--9teDNSpUqYp-mlmU3vb06u7s7MTfoNUiWRYA</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Mildner, Toralf</creator><creator>Norris, David G.</creator><creator>Schwarzbauer, Christian</creator><creator>Wiggins, Christopher J.</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>A qualitative test of the balloon model for BOLD-based MR signal changes at 3T</title><author>Mildner, Toralf ; Norris, David G. ; Schwarzbauer, Christian ; Wiggins, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4004-f5af1ec638d9e65e86279a22129494b48855896ee64d91604553eeebb7cc09423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>3Tesla</topic><topic>balloon model</topic><topic>Biological and medical sciences</topic><topic>BOLD response</topic><topic>Brain - metabolism</topic><topic>Brain - physiology</topic><topic>diffusion weighting</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Photic Stimulation</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mildner, Toralf</creatorcontrib><creatorcontrib>Norris, David G.</creatorcontrib><creatorcontrib>Schwarzbauer, Christian</creatorcontrib><creatorcontrib>Wiggins, Christopher J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mildner, Toralf</au><au>Norris, David G.</au><au>Schwarzbauer, Christian</au><au>Wiggins, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A qualitative test of the balloon model for BOLD-based MR signal changes at 3T</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2001-11</date><risdate>2001</risdate><volume>46</volume><issue>5</issue><spage>891</spage><epage>899</epage><pages>891-899</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>The aim of this study was to adapt the balloon model for BOLD‐based MR signal changes to a magnetic field strength of 3T and to examine its validity. The simultaneous measurement of BOLD and diffusion‐weighted BOLD responses was performed. The amplitude of the BOLD peak was found to be similar for all subjects when a short visual stimulus of 6 sec was used. The rise‐time to the BOLD peak and the shape and depth of the poststimulus undershoot varied significantly. A fit of the experimental BOLD responses was found to be possible by use of parameters within a reasonable physiological range. The relations between these parameters and their influence on the modeled BOLD responses is discussed. A prediction of the balloon model is the occurrence of a BOLD overshoot, i.e., a lag between the changes of the blood volume and the blood flow after the start of the stimulation. Experimental evidence for the existence of a BOLD overshoot is presented. Magn Reson Med 46:891–899, 2001. © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11675640</pmid><doi>10.1002/mrm.1274</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0740-3194 |
| ispartof | Magnetic resonance in medicine, 2001-11, Vol.46 (5), p.891-899 |
| issn | 0740-3194 1522-2594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72225944 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 3Tesla balloon model Biological and medical sciences BOLD response Brain - metabolism Brain - physiology diffusion weighting Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Medical sciences Nervous system Photic Stimulation Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | A qualitative test of the balloon model for BOLD-based MR signal changes at 3T |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T13%3A03%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20qualitative%20test%20of%20the%20balloon%20model%20for%20BOLD-based%20MR%20signal%20changes%20at%203T&rft.jtitle=Magnetic%20resonance%20in%20medicine&rft.au=Mildner,%20Toralf&rft.date=2001-11&rft.volume=46&rft.issue=5&rft.spage=891&rft.epage=899&rft.pages=891-899&rft.issn=0740-3194&rft.eissn=1522-2594&rft.coden=MRMEEN&rft_id=info:doi/10.1002/mrm.1274&rft_dat=%3Cproquest_cross%3E72225944%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72225944&rft_id=info:pmid/11675640&rfr_iscdi=true |