Synthesis of Potent Agonists of the d-myo-Inositol 1,4,5-Trisphosphate Receptor Based on Clustered Disaccharide Polyphosphate Analogues of Adenophostin A

Clustered disaccharide analogues of adenophostin A (2), i.e. mono-, di-, and tetravalent derivatives 6-8, respectively, were synthesized and evaluated as novel ligands for the tetrameric D-myo-inositol 1,4, 5-trisphosphate receptor (IP(3)R). The synthesis was accomplished via Sonogashira coupling of...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-08, Vol.43 (17), p.3295-3303
Hauptverfasser:	DE KORT, Martin, CORREA, Vanessa, VALENTIJN, A. Rob P. M., VAN DER MAREL, Gijs A., POTTER, Barry V. L., TAYLOR, Colin W., VAN BOOM, Jacques H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - chemical synthesis Adenosine - chemistry Adenosine - pharmacology Animals Binding, Competitive Biological and medical sciences Calcium - metabolism Calcium Channels - drug effects Calcium Channels - metabolism Disaccharides - chemical synthesis Disaccharides - chemistry Disaccharides - pharmacology In Vitro Techniques Inositol 1,4,5-Trisphosphate - metabolism Inositol 1,4,5-Trisphosphate Receptors Ligands Liver - cytology Liver - metabolism Male Medical sciences Miscellaneous Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - metabolism Sea Urchins Structure-Activity Relationship
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