Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression: IL-12 and tumor necrosis factor-α synergize for IL-12R expression at low antigen dose

Regulation of the IL-12 receptor (IL-12R) β2 chain has been suggested to function as a molecular switch in determining T cell phenotype. However, because most studies have been carried out under conditions in which cell proliferation was occurring, it has been difficult to distinguish between instru...

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Veröffentlicht in:	International immunology 2001-11, Vol.13 (11), p.1433-1442
Hauptverfasser:	Ahlers, Jeffrey D., Belyakov, Igor M., Matsui, So, Berzofsky, Jay A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals APC antigen-presenting cell Cell Differentiation - drug effects cellular activation CTL cytotoxic T lymphocyte cytokine cytokine receptors Female g-Interferon IL-12R IL-12 receptor Interferon-gamma - biosynthesis interleukin 12 receptors Interleukin-12 - pharmacology Interleukin-12 - physiology Mice Mice, Inbred BALB C OVA ovalbumin ovalbumin Receptors, Interleukin - metabolism Receptors, Interleukin-12 Signal Transduction T lymphocyte T-Lymphocytes - immunology Th1 Cells - immunology Th1/Th2 TNF tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology Up-Regulation
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