Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation

5-HT(1A) receptors are implicated in the aetiology of schizophrenia. Herein, the influence of 15 antipsychotics on the binding of the selective 'neutral' antagonist, [3H]WAY100,635 ([3H]N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)-cyclo-hexanecarboxamide), was examined at...

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Veröffentlicht in:	European journal of pharmacology 2001-10, Vol.428 (2), p.177-184
Hauptverfasser:	Newman-Tancredi, A, Verrièle, L, Touzard, M, Millan, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Binding, Competitive - drug effects Chlorpromazine - pharmacology CHO Cells Clozapine - pharmacology Cricetinae Dose-Response Relationship, Drug GTP-Binding Proteins - drug effects GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Haloperidol - pharmacology Humans Membranes - drug effects Membranes - metabolism Piperazines - metabolism Piperazines - pharmacology Piperidines - pharmacology Pyridines - metabolism Pyrimidinones - pharmacology Pyrrolidines - pharmacology Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT1 Thiazoles - pharmacology Thioridazine - pharmacology Tritium
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