Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

During thymocyte development, high-affinity/avidity TCR engagement leads to the induction of negative selection and apoptosis, while lower TCR affinity-avidity interactions lead to positive selection and survival. To elucidate how these extracellular interactions are translated into intracellular si...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-11, Vol.167 (9), p.4966-4973
Hauptverfasser:	Mariathasan, Sanjeev, Zakarian, Arsen, Bouchard, Denis, Michie, Alison M, Zuniga-Pflucker, Juan Carlos, Ohashi, Pamela S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Clonal Deletion DNA-Binding Proteins - physiology Enzyme Activation ERK kinase MAP Kinase Kinase Kinase 1 Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - physiology Protein-Serine-Threonine Kinases - physiology Receptors, Antigen, T-Cell - physiology T-Lymphocytes - physiology Time Factors
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