Novel Anti-inflammatory Effects of the Inhaled Corticosteroid Fluticasone Propionate During Lung Myofibroblastic Differentiation

Asthma is characterized by an irreversible subepithelial fibrosis with the appearance of myofibroblasts, which can be now considered important early participants in inflammatory responses as well as potential targets for anti-inflammatory drugs. In this study, we show that fluticasone propionate (FP...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-11, Vol.167 (9), p.5329-5337
Hauptverfasser:	Cazes, Eric, Giron-Michel, Julien, Baouz, Soria, Doucet, Christelle, Cagnoni, Francesca, Oddera, Susanna, Korner, Marie, Dasic, Gorana, Testi, Renato, Azzarone, Bruno, Canonica, Giorgio Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - analysis Administration, Inhalation Adult Androstadienes - administration & dosage Androstadienes - pharmacology Anti-Inflammatory Agents - pharmacology Cell Differentiation Cells, Cultured DNA-Binding Proteins - physiology Fibroblasts - drug effects Fibroblasts - physiology Fluticasone fluticasone propionate Humans Interleukin-13 - pharmacology Interleukin-4 - pharmacology Lung - cytology Lung - drug effects Microscopy, Confocal myofibroblasts NF-kappa B - metabolism Protein-Tyrosine Kinases Proteins - physiology Reverse Transcriptase Polymerase Chain Reaction STAT3 Transcription Factor Trans-Activators - physiology TYK2 Kinase
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