Induction of specific CD8+ memory T cells and long lasting protection following immunization with Salmonella typhimurium expressing a lymphocytic choriomeningitis MHC class I-restricted epitope

Numerous studies have shown the potential of Salmonella typhimurium as a vector for delivery of heterologous proteins for vaccination against other pathogens. Earlier studies showed that the inefficient elicitation of MHC class I-restricted responses could limit the use of S. typhimurium as a hetero...

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Veröffentlicht in:	Vaccine 2001-11, Vol.20 (3), p.577-585
Hauptverfasser:	Shams, Homayoun, Poblete, Fernando, Rüssmann, Holger, Galán, Jorge E, Donis, Ruben O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen delivery Antigen-Presenting Cells - physiology Antigen-Presenting Cells - virology Bacterial vaccine vector Biological and medical sciences CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Line Epidemiology. Vaccinations Epitopes, T-Lymphocyte Female Fundamental and applied biological sciences. Psychology General aspects Histocompatibility Antigens Class I - immunology Immunization Immunologic Memory Infectious diseases Lymphocytic choriomeningitis virus - immunology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiology Salmonella typhimurium Salmonella typhimurium - genetics SptP Type III secretion system Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - immunology Viral Vaccines - immunology Virology
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