A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex

Activation of 5-hydroxytryptamine 2A (5-HT 2A) receptors by hallucinogenic drugs is thought to mediate many psychotomimetic effects including changes in affect, cognition and perception. Conversely, blockade of 5-HT 2A receptors may mediate therapeutic effects of many atypical antidepressant and ant...

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Veröffentlicht in:	Neuroscience 2001-01, Vol.105 (2), p.379-392
Hauptverfasser:	Marek, G.J, Wright, R.A, Gewirtz, J.C, Schoepp, D.D
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 2A receptors alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Amygdala - cytology Amygdala - drug effects Amygdala - metabolism Animals Biological and medical sciences Bridged Bicyclo Compounds - pharmacology central medial thalamic nucleus Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Excitatory Amino Acid Agonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Hallucinogens - pharmacology intralaminar and midline thalamic nuclei Male metabotropic glutamate receptors N-Methylaspartate - pharmacology Neural Pathways - cytology Neural Pathways - drug effects Neural Pathways - metabolism prefrontal cortex Prefrontal Cortex - cytology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Pyramidal Cells - cytology Pyramidal Cells - drug effects Pyramidal Cells - metabolism Radioligand Assay Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2A Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - metabolism Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin - metabolism Serotonin - pharmacology Synaptic Transmission - drug effects Synaptic Transmission - physiology thalamocortical terminals Thalamus - cytology Thalamus - drug effects Thalamus - metabolism Vertebrates: nervous system and sense organs
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