Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch

Various Y-shaped branched oligonucleotides containing a 2′- O,3′- C-ethylene linked or 2′- O,4′- C-methylene linked bicyclic nucleotide as branching point were synthesized on an automated DNA synthesizer. Thermal denaturation experiments at 260 and 284 nm showed increased thermal stabilities of comp...

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