Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death

Oligodendrocyte progenitor cells were found to be vulnerable to kainate excitotoxic insults, an effect inhibited by either the selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5 H-2,3-benzodiazepine (GYKI 52466))...

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Veröffentlicht in:	European journal of pharmacology 2001-07, Vol.424 (3), p.R3-R4
Hauptverfasser:	Kelland, Eve E, Toms, Nick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Benzoates - pharmacology Benzodiazepines Biological and medical sciences Cell Death - drug effects Cell Death - physiology Cell Survival - drug effects Cells, Cultured Dose-Response Relationship, Drug Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glutamate receptor Glycine - analogs & derivatives Glycine - pharmacology Kainate Kainic Acid - pharmacology Medical sciences metabotropic Neuropharmacology Neuroprotective agent Oligodendrocyte Oligodendroglia - cytology Oligodendroglia - drug effects Pharmacology. Drug treatments Rats Receptors, AMPA - agonists Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - physiology Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology Resorcinols - pharmacology Stem Cells - cytology Stem Cells - drug effects
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