Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death
Oligodendrocyte progenitor cells were found to be vulnerable to kainate excitotoxic insults, an effect inhibited by either the selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5 H-2,3-benzodiazepine (GYKI 52466))...
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| Veröffentlicht in: | European journal of pharmacology 2001-07, Vol.424 (3), p.R3-R4 |
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| container_title | European journal of pharmacology |
| container_volume | 424 |
| creator | Kelland, Eve E Toms, Nick J |
| description | Oligodendrocyte progenitor cells were found to be vulnerable to kainate excitotoxic insults, an effect inhibited by either the selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5
H-2,3-benzodiazepine (GYKI 52466)) or the selective group I metabotropic glutamate (mGlu) receptor agonist, (
S)-3,5-dihydroxyphenylglycine. The protective effects of (
S)-3,5-dihydroxyphenylglycine were reversed by the selective mGlu receptor antagonist, (
S)-α-methyl-4-carboxyphenylglycine. These data suggest that group I mGlu receptors may limit oligodendrocyte progenitor cell degeneration during acute brain insults. |
| doi_str_mv | 10.1016/S0014-2999(01)01157-8 |
| format | Article |
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S)-α-methyl-4-carboxyphenylglycine. These data suggest that group I mGlu receptors may limit oligodendrocyte progenitor cell degeneration during acute brain insults.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(01)01157-8</identifier><identifier>PMID: 11672568</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anti-Anxiety Agents - pharmacology ; Benzoates - pharmacology ; Benzodiazepines ; Biological and medical sciences ; Cell Death - drug effects ; Cell Death - physiology ; Cell Survival - drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Glutamate receptor ; Glycine - analogs & derivatives ; Glycine - pharmacology ; Kainate ; Kainic Acid - pharmacology ; Medical sciences ; metabotropic ; Neuropharmacology ; Neuroprotective agent ; Oligodendrocyte ; Oligodendroglia - cytology ; Oligodendroglia - drug effects ; Pharmacology. Drug treatments ; Rats ; Receptors, AMPA - agonists ; Receptors, AMPA - antagonists & inhibitors ; Receptors, AMPA - physiology ; Receptors, Metabotropic Glutamate - agonists ; Receptors, Metabotropic Glutamate - antagonists & inhibitors ; Receptors, Metabotropic Glutamate - physiology ; Resorcinols - pharmacology ; Stem Cells - cytology ; Stem Cells - drug effects</subject><ispartof>European journal of pharmacology, 2001-07, Vol.424 (3), p.R3-R4</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-dd06364517af29024003bdd1a41ae4a3f994f0d1a6e238b1e4d92cc2b7d876c53</citedby><cites>FETCH-LOGICAL-c390t-dd06364517af29024003bdd1a41ae4a3f994f0d1a6e238b1e4d92cc2b7d876c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-2999(01)01157-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1080650$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11672568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelland, Eve E</creatorcontrib><creatorcontrib>Toms, Nick J</creatorcontrib><title>Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Oligodendrocyte progenitor cells were found to be vulnerable to kainate excitotoxic insults, an effect inhibited by either the selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5
H-2,3-benzodiazepine (GYKI 52466)) or the selective group I metabotropic glutamate (mGlu) receptor agonist, (
S)-3,5-dihydroxyphenylglycine. The protective effects of (
S)-3,5-dihydroxyphenylglycine were reversed by the selective mGlu receptor antagonist, (
S)-α-methyl-4-carboxyphenylglycine. These data suggest that group I mGlu receptors may limit oligodendrocyte progenitor cell degeneration during acute brain insults.</description><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Benzoates - pharmacology</subject><subject>Benzodiazepines</subject><subject>Biological and medical sciences</subject><subject>Cell Death - drug effects</subject><subject>Cell Death - physiology</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Drug</subject><subject>Excitatory Amino Acid Agonists - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Glutamate receptor</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - pharmacology</subject><subject>Kainate</subject><subject>Kainic Acid - pharmacology</subject><subject>Medical sciences</subject><subject>metabotropic</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Oligodendrocyte</subject><subject>Oligodendroglia - cytology</subject><subject>Oligodendroglia - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Receptors, AMPA - agonists</subject><subject>Receptors, AMPA - antagonists & inhibitors</subject><subject>Receptors, AMPA - physiology</subject><subject>Receptors, Metabotropic Glutamate - agonists</subject><subject>Receptors, Metabotropic Glutamate - antagonists & inhibitors</subject><subject>Receptors, Metabotropic Glutamate - physiology</subject><subject>Resorcinols - pharmacology</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQhi0EokvhEUA5IASHwIyTOPEJrSoolVqBBJwtx54shiQOtoPUt6-3u2p74zTy6PvHvz7GXiK8R0Dx4TsA1iWXUr4FfAeITVt2j9gGu1aW0CJ_zDZ3yAl7FuNvAGgkb56yE0TR8kZ0G_bnPPh1KS6KiZLufQp-cabYjWvSk05UBDK0JB9iMbrJpWJ79W17tywnsi5TtvCj23lLsw3eXOfYEvyOZpeZwtA4FpZ0-vWcPRn0GOnFcZ6yn58__Tj7Ul5-Pb84216WppKQSmtBVKJusNUDl8BrgKq3FnWNmmpdDVLWA-S3IF51PVJtJTeG963tWmGa6pS9OdzNLf6uFJOaXNzX0DP5NaqWc16hwAw2B9AEH2OgQS3BTTpcKwS1t6xuLau9QgWobi2rLudeHT9Y-6zgPnXUmoHXR0BHo8ch6Nm4-OB6B6KBjH08YJRt_HMUVDSOZpOtZsVJWe_-0-QGLHqagw</recordid><startdate>20010727</startdate><enddate>20010727</enddate><creator>Kelland, Eve E</creator><creator>Toms, Nick J</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010727</creationdate><title>Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death</title><author>Kelland, Eve E ; Toms, Nick J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-dd06364517af29024003bdd1a41ae4a3f994f0d1a6e238b1e4d92cc2b7d876c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Benzoates - pharmacology</topic><topic>Benzodiazepines</topic><topic>Biological and medical sciences</topic><topic>Cell Death - drug effects</topic><topic>Cell Death - physiology</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Dose-Response Relationship, Drug</topic><topic>Excitatory Amino Acid Agonists - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Glutamate receptor</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - pharmacology</topic><topic>Kainate</topic><topic>Kainic Acid - pharmacology</topic><topic>Medical sciences</topic><topic>metabotropic</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Oligodendrocyte</topic><topic>Oligodendroglia - cytology</topic><topic>Oligodendroglia - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Receptors, AMPA - agonists</topic><topic>Receptors, AMPA - antagonists & inhibitors</topic><topic>Receptors, AMPA - physiology</topic><topic>Receptors, Metabotropic Glutamate - agonists</topic><topic>Receptors, Metabotropic Glutamate - antagonists & inhibitors</topic><topic>Receptors, Metabotropic Glutamate - physiology</topic><topic>Resorcinols - pharmacology</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelland, Eve E</creatorcontrib><creatorcontrib>Toms, Nick J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelland, Eve E</au><au>Toms, Nick J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2001-07-27</date><risdate>2001</risdate><volume>424</volume><issue>3</issue><spage>R3</spage><epage>R4</epage><pages>R3-R4</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Oligodendrocyte progenitor cells were found to be vulnerable to kainate excitotoxic insults, an effect inhibited by either the selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5
H-2,3-benzodiazepine (GYKI 52466)) or the selective group I metabotropic glutamate (mGlu) receptor agonist, (
S)-3,5-dihydroxyphenylglycine. The protective effects of (
S)-3,5-dihydroxyphenylglycine were reversed by the selective mGlu receptor antagonist, (
S)-α-methyl-4-carboxyphenylglycine. These data suggest that group I mGlu receptors may limit oligodendrocyte progenitor cell degeneration during acute brain insults.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11672568</pmid><doi>10.1016/S0014-2999(01)01157-8</doi></addata></record> |
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| issn | 0014-2999 1879-0712 |
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| subjects | Animals Anti-Anxiety Agents - pharmacology Benzoates - pharmacology Benzodiazepines Biological and medical sciences Cell Death - drug effects Cell Death - physiology Cell Survival - drug effects Cells, Cultured Dose-Response Relationship, Drug Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glutamate receptor Glycine - analogs & derivatives Glycine - pharmacology Kainate Kainic Acid - pharmacology Medical sciences metabotropic Neuropharmacology Neuroprotective agent Oligodendrocyte Oligodendroglia - cytology Oligodendroglia - drug effects Pharmacology. Drug treatments Rats Receptors, AMPA - agonists Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - physiology Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology Resorcinols - pharmacology Stem Cells - cytology Stem Cells - drug effects |
| title | Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death |
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