Angiostatin Induces Mitotic Cell Death of Proliferating Endothelial Cells
Angiostatin is an inhibitor of tumor angiogenesis that induces regression of experimental tumors and enhances the antitumor effects of radiation therapy. We report that the cytotoxic effects of angiostatin are restricted to the proliferating endothelial cell population. In addition, angiostatin and...
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| Veröffentlicht in: | Molecular cell biology research communications 2000-05, Vol.3 (5), p.277-282 |
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| container_end_page | 282 |
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| container_title | Molecular cell biology research communications |
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| creator | Hari, Danielle Beckett, Michael A. Sukhatme, Vikas P. Dhanabal, Mohanraj Nodzenski, Edwardine Lu, Hua Mauceri, Helena J. Kufe, Donald W. Weichselbaum, Ralph R. |
| description | Angiostatin is an inhibitor of tumor angiogenesis that induces regression of experimental tumors and enhances the antitumor effects of radiation therapy. We report that the cytotoxic effects of angiostatin are restricted to the proliferating endothelial cell population. In addition, angiostatin and ionizing radiation (IR) interact by inducing death of dividing endothelial cells. We also show that angiostatin and IR interact to inhibit endothelial cell migration. These findings demonstrate that angiostatin targets the proliferating tumor vasculature and provide a mechanistic basis for the cytotoxic interaction of angiostatin and IR. |
| doi_str_mv | 10.1006/mcbr.2000.0222 |
| format | Article |
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We report that the cytotoxic effects of angiostatin are restricted to the proliferating endothelial cell population. In addition, angiostatin and ionizing radiation (IR) interact by inducing death of dividing endothelial cells. We also show that angiostatin and IR interact to inhibit endothelial cell migration. These findings demonstrate that angiostatin targets the proliferating tumor vasculature and provide a mechanistic basis for the cytotoxic interaction of angiostatin and IR.</description><identifier>ISSN: 1522-4724</identifier><identifier>EISSN: 1522-4732</identifier><identifier>DOI: 10.1006/mcbr.2000.0222</identifier><identifier>PMID: 10964751</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Angiogenesis Inhibitors - metabolism ; Angiogenesis Inhibitors - pharmacology ; Angiostatins ; Animals ; Antineoplastic Agents - metabolism ; Antineoplastic Agents - pharmacology ; Aorta - cytology ; Cattle ; Cell Death - drug effects ; Cell Division - drug effects ; Cell Migration Inhibition ; Cells, Cultured ; Endothelium, Vascular - cytology ; Endothelium, Vascular - physiology ; Endothelium, Vascular - radiation effects ; Humans ; Mitosis ; Peptide Fragments - genetics ; Peptide Fragments - metabolism ; Peptide Fragments - pharmacology ; Plasminogen - genetics ; Plasminogen - metabolism ; Plasminogen - pharmacology ; Radiation, Ionizing ; Recombinant Proteins - metabolism ; Umbilical Veins - cytology</subject><ispartof>Molecular cell biology research communications, 2000-05, Vol.3 (5), p.277-282</ispartof><rights>2000 Academic Press</rights><rights>Copyright 2000 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c255t-af1f53769f445332d40ca6d10f1b8d279253c7c58daf00cfcb94d836de49d2513</citedby><cites>FETCH-LOGICAL-c255t-af1f53769f445332d40ca6d10f1b8d279253c7c58daf00cfcb94d836de49d2513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10964751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hari, Danielle</creatorcontrib><creatorcontrib>Beckett, Michael A.</creatorcontrib><creatorcontrib>Sukhatme, Vikas P.</creatorcontrib><creatorcontrib>Dhanabal, Mohanraj</creatorcontrib><creatorcontrib>Nodzenski, Edwardine</creatorcontrib><creatorcontrib>Lu, Hua</creatorcontrib><creatorcontrib>Mauceri, Helena J.</creatorcontrib><creatorcontrib>Kufe, Donald W.</creatorcontrib><creatorcontrib>Weichselbaum, Ralph R.</creatorcontrib><title>Angiostatin Induces Mitotic Cell Death of Proliferating Endothelial Cells</title><title>Molecular cell biology research communications</title><addtitle>Mol Cell Biol Res Commun</addtitle><description>Angiostatin is an inhibitor of tumor angiogenesis that induces regression of experimental tumors and enhances the antitumor effects of radiation therapy. We report that the cytotoxic effects of angiostatin are restricted to the proliferating endothelial cell population. In addition, angiostatin and ionizing radiation (IR) interact by inducing death of dividing endothelial cells. We also show that angiostatin and IR interact to inhibit endothelial cell migration. These findings demonstrate that angiostatin targets the proliferating tumor vasculature and provide a mechanistic basis for the cytotoxic interaction of angiostatin and IR.</description><subject>Angiogenesis Inhibitors - metabolism</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Angiostatins</subject><subject>Animals</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Aorta - cytology</subject><subject>Cattle</subject><subject>Cell Death - drug effects</subject><subject>Cell Division - drug effects</subject><subject>Cell Migration Inhibition</subject><subject>Cells, Cultured</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Endothelium, Vascular - radiation effects</subject><subject>Humans</subject><subject>Mitosis</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - metabolism</subject><subject>Peptide Fragments - pharmacology</subject><subject>Plasminogen - genetics</subject><subject>Plasminogen - metabolism</subject><subject>Plasminogen - pharmacology</subject><subject>Radiation, Ionizing</subject><subject>Recombinant Proteins - metabolism</subject><subject>Umbilical Veins - cytology</subject><issn>1522-4724</issn><issn>1522-4732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EolBYGVEmtgTbifMxVqVApSIYYLYc-9waJXGxHST-PQmpEAvT3fC8r-4ehK4ITgjG-W0ra5dQjHGCKaVH6IwwSuOsSOnx706zGTr3_n2gckKKUzQjuMqzgpEztF50W2N9EMF00bpTvQQfPZlgg5HREpomugMRdpHV0YuzjdHgRnQbrTplww4aI5ofzl-gEy0aD5eHOUdv96vX5WO8eX5YLxebWFLGQiw00Swt8kpnGUtTqjIsRa4I1qQuFS0qylJZSFYqoTGWWtZVpso0V5BVijKSztHN1Lt39qMHH3hrvBwuEB3Y3vNi8EAJqQYwmUDprPcONN870wr3xQnmozw-yuOjPD7KGwLXh-a-bkH9wSdbA1BOAAz_fRpw3EsDnQRlHMjAlTX_dX8D-_59VA</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Hari, Danielle</creator><creator>Beckett, Michael A.</creator><creator>Sukhatme, Vikas P.</creator><creator>Dhanabal, Mohanraj</creator><creator>Nodzenski, Edwardine</creator><creator>Lu, Hua</creator><creator>Mauceri, Helena J.</creator><creator>Kufe, Donald W.</creator><creator>Weichselbaum, Ralph R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>Angiostatin Induces Mitotic Cell Death of Proliferating Endothelial Cells</title><author>Hari, Danielle ; 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| subjects | Angiogenesis Inhibitors - metabolism Angiogenesis Inhibitors - pharmacology Angiostatins Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Aorta - cytology Cattle Cell Death - drug effects Cell Division - drug effects Cell Migration Inhibition Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - physiology Endothelium, Vascular - radiation effects Humans Mitosis Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - pharmacology Plasminogen - genetics Plasminogen - metabolism Plasminogen - pharmacology Radiation, Ionizing Recombinant Proteins - metabolism Umbilical Veins - cytology |
| title | Angiostatin Induces Mitotic Cell Death of Proliferating Endothelial Cells |
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