Regulation of Insulin-like Growth Factor Binding Protein-5 mRNA Abundance in Rat Intestinal Smooth Muscle

IGF-I increases abundance of IGFBP-5 mRNA in rat intestinal smooth muscle cells (RISM), and IGFBP-5 protein in RISM conditioned media. The translational blocker, cycloheximide, decreased the abundance of IGFBP-5 mRNA to undetectable levels, suggesting that IGFBP-5 mRNA integrity is linked to protein...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-08, Vol.275 (2), p.422-427
Hauptverfasser:	Hou, Y.T., Xin, X.P., Li, L., Zimmerman, E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 5' Untranslated Regions Animals Base Sequence Cell Nucleus - metabolism Cells, Cultured Cloning, Molecular Colon - cytology Colon - metabolism cycloheximide Cycloheximide - pharmacology cytoplasmic extract DNA Primers IGF-I IGFBP-5 Insulin-Like Growth Factor Binding Protein 5 - genetics Insulin-Like Growth Factor I - pharmacology insulin-like growth factor-binding protein 5 mRNA binding proteins Muscle, Smooth - metabolism protein synthesis inhibitor Protein Synthesis Inhibitors - pharmacology puromycin Rats Rats, Inbred Lew RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics
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