GEF at work: Vav in protruding filopodia

The Dbl family proto‐oncogene vav is a nucleotide exchange factor for Rho family GTPases and is involved in triggering cytoskeletal changes contributing to the alterations of cell shape and motility, as well as in the induction of gene expression. In vitro and in vivo Vav is regulated by multiple ty...

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Veröffentlicht in:	Cell motility and the cytoskeleton 2001-07, Vol.49 (3), p.154-160
Hauptverfasser:	Kranewitter, Wolfgang J., Danninger, Claudia, Gimona, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Cell Movement - physiology Cell Size - physiology Cell Surface Extensions - physiology Cytoskeleton - metabolism Cytoskeleton - ultrastructure dynamics filopodia Gene Expression - physiology green fluorescent protein Guanine Nucleotide Exchange Factors - metabolism localization localization, dynamics Melanoma - metabolism Mice Microscopy, Fluorescence Mutation - physiology Oncogene Proteins - metabolism Phosphorylation Proto-Oncogene Proteins c-vav Pseudopodia - physiology Subcellular Fractions - metabolism Tumor Cells, Cultured - metabolism vav
Online-Zugang:	Volltext
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