Impaired immunogenicity of immunostimulating complexes (iscoms) by administration in slow-release formulations
This study was performed to explore the possible benefits of formulations and administration regimens that allow a protracted release of iscoms from the injection site. Three forms of slow release of immunostimulating complexes (iscoms) were therefore tested; encapsulation in sodium alginate gel, em...
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| Veröffentlicht in: | Microbes and infection 2000-07, Vol.2 (9), p.1003-1010 |
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| creator | Johansson, Margaretha Ranlund, Katarina Lövgren-Bengtsson, Karin |
| description | This study was performed to explore the possible benefits of formulations and administration regimens that allow a protracted release of iscoms from the injection site. Three forms of slow release of immunostimulating complexes (iscoms) were therefore tested; encapsulation in sodium alginate gel, emulsification in Freund′s incomplete adjuvant (FIA) or pulsed-release mimicked by weekly administrations. The administration of iscoms in a depot (alginate or FIA) or in pulses resulted in an antibody response of similar magnitude to that of a traditional two-dose scheme. The character of the immune response was on the other hand affected, i.e. the proportion of specific IgG2a and the IFN-γ production was decreased by a protracted or repeated release of iscoms, either by a depot or by weekly administrations. |
| doi_str_mv | 10.1016/S1286-4579(00)01254-5 |
| format | Article |
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Three forms of slow release of immunostimulating complexes (iscoms) were therefore tested; encapsulation in sodium alginate gel, emulsification in Freund′s incomplete adjuvant (FIA) or pulsed-release mimicked by weekly administrations. The administration of iscoms in a depot (alginate or FIA) or in pulses resulted in an antibody response of similar magnitude to that of a traditional two-dose scheme. The character of the immune response was on the other hand affected, i.e. the proportion of specific IgG2a and the IFN-γ production was decreased by a protracted or repeated release of iscoms, either by a depot or by weekly administrations.</description><identifier>ISSN: 1286-4579</identifier><identifier>EISSN: 1769-714X</identifier><identifier>DOI: 10.1016/S1286-4579(00)01254-5</identifier><identifier>PMID: 10967281</identifier><language>eng</language><publisher>Lausanne: Elsevier SAS</publisher><subject>adjuvant ; Alginates ; Animals ; Antigens, Viral - immunology ; Biological and medical sciences ; Bone Marrow - immunology ; Cytokines - analysis ; Delayed-Action Preparations ; Female ; FIA ; Freund's Adjuvant ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; g-Interferon ; Gels ; Glucuronic Acid ; Hexuronic Acids ; Immunobiology ; Immunoglobulin G - analysis ; immunoglobulin G2 ; immunomodulation ; Immunomodulators ; Influenza A virus - immunology ; Interferon-gamma - analysis ; iscom ; ISCOMs - administration & dosage ; ISCOMs - immunology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Modulation of the immune response (stimulation, suppression) ; Pharmacology. Drug treatments ; Pulse Therapy, Drug ; slow release ; sodium alginate ; Specific Pathogen-Free Organisms ; Spleen - cytology ; Spleen - immunology ; Vaccines, Synthetic - immunology</subject><ispartof>Microbes and infection, 2000-07, Vol.2 (9), p.1003-1010</ispartof><rights>2000 Éditions scientifiques et médicales Elsevier SAS</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-5ad2565f4452651320f8cfe20451f45c9247b3abc431750087fcdda5a1af400a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1286-4579(00)01254-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=905916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10967281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johansson, Margaretha</creatorcontrib><creatorcontrib>Ranlund, Katarina</creatorcontrib><creatorcontrib>Lövgren-Bengtsson, Karin</creatorcontrib><title>Impaired immunogenicity of immunostimulating complexes (iscoms) by administration in slow-release formulations</title><title>Microbes and infection</title><addtitle>Microbes Infect</addtitle><description>This study was performed to explore the possible benefits of formulations and administration regimens that allow a protracted release of iscoms from the injection site. Three forms of slow release of immunostimulating complexes (iscoms) were therefore tested; encapsulation in sodium alginate gel, emulsification in Freund′s incomplete adjuvant (FIA) or pulsed-release mimicked by weekly administrations. The administration of iscoms in a depot (alginate or FIA) or in pulses resulted in an antibody response of similar magnitude to that of a traditional two-dose scheme. The character of the immune response was on the other hand affected, i.e. the proportion of specific IgG2a and the IFN-γ production was decreased by a protracted or repeated release of iscoms, either by a depot or by weekly administrations.</description><subject>adjuvant</subject><subject>Alginates</subject><subject>Animals</subject><subject>Antigens, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - immunology</subject><subject>Cytokines - analysis</subject><subject>Delayed-Action Preparations</subject><subject>Female</subject><subject>FIA</subject><subject>Freund's Adjuvant</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>g-Interferon</subject><subject>Gels</subject><subject>Glucuronic Acid</subject><subject>Hexuronic Acids</subject><subject>Immunobiology</subject><subject>Immunoglobulin G - analysis</subject><subject>immunoglobulin G2</subject><subject>immunomodulation</subject><subject>Immunomodulators</subject><subject>Influenza A virus - immunology</subject><subject>Interferon-gamma - analysis</subject><subject>iscom</subject><subject>ISCOMs - administration & dosage</subject><subject>ISCOMs - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulse Therapy, Drug</subject><subject>slow release</subject><subject>sodium alginate</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>Vaccines, Synthetic - immunology</subject><issn>1286-4579</issn><issn>1769-714X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrFTEUgINYbK3-BGVAKO1i9JxMHjOrIsVHoeBCBXchN5OUyCS5JjPa--_N7Vylu65ycvjOg_MR8grhLQKKd1-R9qJlXA7nABeAlLOWPyEnKMXQSmQ_ntb4H3JMnpfyEwC5FOwZOUYYhKQ9npB4HbbaZzs2PoQlplsbvfHzrknukCmzD8ukZx9vG5PCdrJ3tjTnvtRPuWg2u0aPwUdf5lyhFBsfmzKlP222k9XFNi7ltUGK5QU5cnoq9uXhPSXfP374dvW5vfny6frq_U1rOtHPLdcj5YI7xjgVHDsKrjfOUmAcHeNmoExuOr0xrEPJAXrpzDhqrlE7BqC7U3K29t3m9GuxZVahLmynSUeblqIkpRQ58kdBlBK6bpAV5CtociolW6e22QeddwpB7Y2oeyNqf24FoO6NqP2A14cByybY8UHVqqACbw6ALkZPLutofPnPDcAHFJW6XClbr_bb26yK8TYaO1Z5ZlZj8o8s8hcQsamY</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Johansson, Margaretha</creator><creator>Ranlund, Katarina</creator><creator>Lövgren-Bengtsson, Karin</creator><general>Elsevier SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Impaired immunogenicity of immunostimulating complexes (iscoms) by administration in slow-release formulations</title><author>Johansson, Margaretha ; Ranlund, Katarina ; Lövgren-Bengtsson, Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-5ad2565f4452651320f8cfe20451f45c9247b3abc431750087fcdda5a1af400a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>adjuvant</topic><topic>Alginates</topic><topic>Animals</topic><topic>Antigens, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - immunology</topic><topic>Cytokines - analysis</topic><topic>Delayed-Action Preparations</topic><topic>Female</topic><topic>FIA</topic><topic>Freund's Adjuvant</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>g-Interferon</topic><topic>Gels</topic><topic>Glucuronic Acid</topic><topic>Hexuronic Acids</topic><topic>Immunobiology</topic><topic>Immunoglobulin G - analysis</topic><topic>immunoglobulin G2</topic><topic>immunomodulation</topic><topic>Immunomodulators</topic><topic>Influenza A virus - immunology</topic><topic>Interferon-gamma - analysis</topic><topic>iscom</topic><topic>ISCOMs - administration & dosage</topic><topic>ISCOMs - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulse Therapy, Drug</topic><topic>slow release</topic><topic>sodium alginate</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>Vaccines, Synthetic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johansson, Margaretha</creatorcontrib><creatorcontrib>Ranlund, Katarina</creatorcontrib><creatorcontrib>Lövgren-Bengtsson, Karin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microbes and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johansson, Margaretha</au><au>Ranlund, Katarina</au><au>Lövgren-Bengtsson, Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired immunogenicity of immunostimulating complexes (iscoms) by administration in slow-release formulations</atitle><jtitle>Microbes and infection</jtitle><addtitle>Microbes Infect</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>2</volume><issue>9</issue><spage>1003</spage><epage>1010</epage><pages>1003-1010</pages><issn>1286-4579</issn><eissn>1769-714X</eissn><abstract>This study was performed to explore the possible benefits of formulations and administration regimens that allow a protracted release of iscoms from the injection site. Three forms of slow release of immunostimulating complexes (iscoms) were therefore tested; encapsulation in sodium alginate gel, emulsification in Freund′s incomplete adjuvant (FIA) or pulsed-release mimicked by weekly administrations. The administration of iscoms in a depot (alginate or FIA) or in pulses resulted in an antibody response of similar magnitude to that of a traditional two-dose scheme. The character of the immune response was on the other hand affected, i.e. the proportion of specific IgG2a and the IFN-γ production was decreased by a protracted or repeated release of iscoms, either by a depot or by weekly administrations.</abstract><cop>Lausanne</cop><cop>Amsterdam</cop><cop>Paris</cop><pub>Elsevier SAS</pub><pmid>10967281</pmid><doi>10.1016/S1286-4579(00)01254-5</doi><tpages>8</tpages></addata></record> |
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| subjects | adjuvant Alginates Animals Antigens, Viral - immunology Biological and medical sciences Bone Marrow - immunology Cytokines - analysis Delayed-Action Preparations Female FIA Freund's Adjuvant Fundamental and applied biological sciences. Psychology Fundamental immunology g-Interferon Gels Glucuronic Acid Hexuronic Acids Immunobiology Immunoglobulin G - analysis immunoglobulin G2 immunomodulation Immunomodulators Influenza A virus - immunology Interferon-gamma - analysis iscom ISCOMs - administration & dosage ISCOMs - immunology Medical sciences Mice Mice, Inbred BALB C Modulation of the immune response (stimulation, suppression) Pharmacology. Drug treatments Pulse Therapy, Drug slow release sodium alginate Specific Pathogen-Free Organisms Spleen - cytology Spleen - immunology Vaccines, Synthetic - immunology |
| title | Impaired immunogenicity of immunostimulating complexes (iscoms) by administration in slow-release formulations |
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