The role of α-CaMKII autophosphorylation in neocortical experience-dependent plasticity

Calcium/calmodulin kinase type II (CaMKII) is a major postsynaptic density protein. CaMKII is postulated to act as a ‘molecular switch’, which, when triggered by a transient rise in calcium influx, becomes active for prolonged periods because of its ability to autophosphorylate. We studied experienc...

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Veröffentlicht in:	Nature neuroscience 2000-09, Vol.3 (9), p.911-918
Hauptverfasser:	Fox, K, Glazewski, S, Giese, K. P, Silva, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation (Physiology) Age Factors Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - deficiency Calcium-Calmodulin-Dependent Protein Kinases - genetics Heterozygote Learning - physiology Mechanoreceptors - cytology Mechanoreceptors - metabolism Mice Mice, Knockout Neocortex - cytology Neocortex - growth & development Neocortex - metabolism Neurobiology Neuronal Plasticity - physiology Neurons - cytology Neurons - metabolism Neurosciences Phosphorylation Physiological aspects Point Mutation - physiology Protein kinases Somatosensory Cortex - cytology Somatosensory Cortex - growth & development Somatosensory Cortex - metabolism Synapses - metabolism Synapses - ultrastructure Vibrissae - innervation Vibrissae - physiology
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