Atypical glandular cells of undetermined significance : Clinically significant lesions and means of patient follow-up
The clinical significance of atypical glandular cells of undetermined significance (AGUS) remains poorly understood, and patient management is not standardized. The authors evaluated the rate, qualification, and follow-up (FU) findings of AGUS patients. Computerized records from the authors' in...
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| Veröffentlicht in: | Cancer 2000-08, Vol.90 (4), p.207-214 |
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| description | The clinical significance of atypical glandular cells of undetermined significance (AGUS) remains poorly understood, and patient management is not standardized. The authors evaluated the rate, qualification, and follow-up (FU) findings of AGUS patients.
Computerized records from the authors' institution were searched from April 1992 to December 1997 for diagnoses of AGUS. Results of cytologic and histologic FU were evaluated up to 48 months of FU. Clinically significant lesions were defined as squamous intraepithelial lesion (SIL), endometrial pathology of hyperplasia or higher, adenocarcinoma in situ (AIS), or invasive adenocarcinoma.
AGUS was diagnosed in 92 of 87,632 patients (0.11%). FU data were available from 69 patients, consisting of smears and/or surgical pathology specimens from the cervix, endometrium, or ovary. Forty patients had FU smears only, 13 had histologic FU only, and 16 had both. Seventeen patients (25%; 15 patients with unqualified AGUS and 2 patients with "favor endometrial origin" according to the Bethesda System of AGUS subclassification) had clinically significant lesions: high grade SIL (n = 8 patients), low grade SIL (n = 2 patients), endometrial lesion (n = 5 patients), AIS (n = 1 patient), and invasive cervical adenocarcinoma (n = 1 patient). It is noteworthy that 4 patients with carcinoma (3 patients with AIS and 1 patient with invasive carcinoma) were diagnosed after a long FU (36-48 months). The remaining 13 lesions were detected at first FU (1-24 months). Six lesions were detected on FU smear, whereas 15 were detected histologically (4 lesions were detected in both).
AGUS is associated with clinically significant lesions in 25% of patients who are followed. Most of the lesions were high grade and were detected histologically. Moreover, 4 of 17 lesions were detected after a FU period ranging from 36 months to 48 months. The role of qualifying AGUS needs further study. Cancer (Cancer Cytopathol) |
| doi_str_mv | 10.1002/1097-0142(20000825)90:4<207::AID-CNCR2>3.0.CO;2-H |
| format | Article |
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Computerized records from the authors' institution were searched from April 1992 to December 1997 for diagnoses of AGUS. Results of cytologic and histologic FU were evaluated up to 48 months of FU. Clinically significant lesions were defined as squamous intraepithelial lesion (SIL), endometrial pathology of hyperplasia or higher, adenocarcinoma in situ (AIS), or invasive adenocarcinoma.
AGUS was diagnosed in 92 of 87,632 patients (0.11%). FU data were available from 69 patients, consisting of smears and/or surgical pathology specimens from the cervix, endometrium, or ovary. Forty patients had FU smears only, 13 had histologic FU only, and 16 had both. Seventeen patients (25%; 15 patients with unqualified AGUS and 2 patients with "favor endometrial origin" according to the Bethesda System of AGUS subclassification) had clinically significant lesions: high grade SIL (n = 8 patients), low grade SIL (n = 2 patients), endometrial lesion (n = 5 patients), AIS (n = 1 patient), and invasive cervical adenocarcinoma (n = 1 patient). It is noteworthy that 4 patients with carcinoma (3 patients with AIS and 1 patient with invasive carcinoma) were diagnosed after a long FU (36-48 months). The remaining 13 lesions were detected at first FU (1-24 months). Six lesions were detected on FU smear, whereas 15 were detected histologically (4 lesions were detected in both).
AGUS is associated with clinically significant lesions in 25% of patients who are followed. Most of the lesions were high grade and were detected histologically. Moreover, 4 of 17 lesions were detected after a FU period ranging from 36 months to 48 months. The role of qualifying AGUS needs further study. Cancer (Cancer Cytopathol)</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(20000825)90:4<207::AID-CNCR2>3.0.CO;2-H</identifier><identifier>PMID: 10966560</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York, NY: Wiley-Liss</publisher><subject>Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma in Situ - pathology ; Cervical Intraepithelial Neoplasia - pathology ; Cervix Uteri - pathology ; Endometrial Neoplasms - pathology ; Endometrium - pathology ; Female ; Follow-Up Studies ; Genital system. Mammary gland ; Humans ; Hyperplasia - pathology ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Middle Aged ; Ovarian Neoplasms - pathology ; Ovary - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Retrospective Studies ; Uterine Cervical Neoplasms - pathology ; Vaginal Smears</subject><ispartof>Cancer, 2000-08, Vol.90 (4), p.207-214</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c310t-7099ea54af5499261bec3ce89baa25f88d0e07d86e237d0b7287181416ed4b2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1467439$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10966560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SOOFER, S. B</creatorcontrib><creatorcontrib>SIDAWY, M. K</creatorcontrib><title>Atypical glandular cells of undetermined significance : Clinically significant lesions and means of patient follow-up</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The clinical significance of atypical glandular cells of undetermined significance (AGUS) remains poorly understood, and patient management is not standardized. The authors evaluated the rate, qualification, and follow-up (FU) findings of AGUS patients.
Computerized records from the authors' institution were searched from April 1992 to December 1997 for diagnoses of AGUS. Results of cytologic and histologic FU were evaluated up to 48 months of FU. Clinically significant lesions were defined as squamous intraepithelial lesion (SIL), endometrial pathology of hyperplasia or higher, adenocarcinoma in situ (AIS), or invasive adenocarcinoma.
AGUS was diagnosed in 92 of 87,632 patients (0.11%). FU data were available from 69 patients, consisting of smears and/or surgical pathology specimens from the cervix, endometrium, or ovary. Forty patients had FU smears only, 13 had histologic FU only, and 16 had both. Seventeen patients (25%; 15 patients with unqualified AGUS and 2 patients with "favor endometrial origin" according to the Bethesda System of AGUS subclassification) had clinically significant lesions: high grade SIL (n = 8 patients), low grade SIL (n = 2 patients), endometrial lesion (n = 5 patients), AIS (n = 1 patient), and invasive cervical adenocarcinoma (n = 1 patient). It is noteworthy that 4 patients with carcinoma (3 patients with AIS and 1 patient with invasive carcinoma) were diagnosed after a long FU (36-48 months). The remaining 13 lesions were detected at first FU (1-24 months). Six lesions were detected on FU smear, whereas 15 were detected histologically (4 lesions were detected in both).
AGUS is associated with clinically significant lesions in 25% of patients who are followed. Most of the lesions were high grade and were detected histologically. Moreover, 4 of 17 lesions were detected after a FU period ranging from 36 months to 48 months. The role of qualifying AGUS needs further study. Cancer (Cancer Cytopathol)</description><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma in Situ - pathology</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervix Uteri - pathology</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Hyperplasia - pathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovary - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Retrospective Studies</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Vaginal Smears</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkd2L1DAUxYMo7jj6L0geRNyHjjcfbZpZEYb6MQuLg6LgW0jb2yWSfti0LPPfm-6MunkJl3vOCfkdQjSDDQPgbxlolQCT_A2HeHKeXmrYyncc1Ha7u_6QFF-Kb_y92MCmOFzxZP-IrP55HpPV4klSKX5ekGch_Iqj4ql4Si6iKMvSDFZk3k3HwVXW01tvu3r2dqQVeh9o39C5q3HCsXUd1jS42841UdpVSLe08K5bfP74YDNRj8H1XaAxi7Zou_ucwU4O47Lpve_vknl4Tp401gd8cb7X5Menj9-LfXJz-Hxd7G6SSjCYEgVao02lbVKpNc9YiZWoMNeltTxt8rwGBFXnGXKhaigVzxXLmWQZ1rLkVqzJ61PuMPa_ZwyTaV1Yvmc77OdgFOccWCS0Jl9PwmrsQxixMcPoWjseDQOzdGEWrmbhav52YTQYGSdlTOzC3HdhhAFTHAw3-5j58vz4XLZYP0g8wY-CV2eBDZFkM0a0LvzXyUxJocUfrPmYGw</recordid><startdate>20000825</startdate><enddate>20000825</enddate><creator>SOOFER, S. B</creator><creator>SIDAWY, M. K</creator><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000825</creationdate><title>Atypical glandular cells of undetermined significance : Clinically significant lesions and means of patient follow-up</title><author>SOOFER, S. B ; SIDAWY, M. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-7099ea54af5499261bec3ce89baa25f88d0e07d86e237d0b7287181416ed4b2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma in Situ - pathology</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervix Uteri - pathology</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Hyperplasia - pathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovary - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Retrospective Studies</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Vaginal Smears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SOOFER, S. B</creatorcontrib><creatorcontrib>SIDAWY, M. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SOOFER, S. B</au><au>SIDAWY, M. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atypical glandular cells of undetermined significance : Clinically significant lesions and means of patient follow-up</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2000-08-25</date><risdate>2000</risdate><volume>90</volume><issue>4</issue><spage>207</spage><epage>214</epage><pages>207-214</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>The clinical significance of atypical glandular cells of undetermined significance (AGUS) remains poorly understood, and patient management is not standardized. The authors evaluated the rate, qualification, and follow-up (FU) findings of AGUS patients.
Computerized records from the authors' institution were searched from April 1992 to December 1997 for diagnoses of AGUS. Results of cytologic and histologic FU were evaluated up to 48 months of FU. Clinically significant lesions were defined as squamous intraepithelial lesion (SIL), endometrial pathology of hyperplasia or higher, adenocarcinoma in situ (AIS), or invasive adenocarcinoma.
AGUS was diagnosed in 92 of 87,632 patients (0.11%). FU data were available from 69 patients, consisting of smears and/or surgical pathology specimens from the cervix, endometrium, or ovary. Forty patients had FU smears only, 13 had histologic FU only, and 16 had both. Seventeen patients (25%; 15 patients with unqualified AGUS and 2 patients with "favor endometrial origin" according to the Bethesda System of AGUS subclassification) had clinically significant lesions: high grade SIL (n = 8 patients), low grade SIL (n = 2 patients), endometrial lesion (n = 5 patients), AIS (n = 1 patient), and invasive cervical adenocarcinoma (n = 1 patient). It is noteworthy that 4 patients with carcinoma (3 patients with AIS and 1 patient with invasive carcinoma) were diagnosed after a long FU (36-48 months). The remaining 13 lesions were detected at first FU (1-24 months). Six lesions were detected on FU smear, whereas 15 were detected histologically (4 lesions were detected in both).
AGUS is associated with clinically significant lesions in 25% of patients who are followed. Most of the lesions were high grade and were detected histologically. Moreover, 4 of 17 lesions were detected after a FU period ranging from 36 months to 48 months. The role of qualifying AGUS needs further study. Cancer (Cancer Cytopathol)</abstract><cop>New York, NY</cop><pub>Wiley-Liss</pub><pmid>10966560</pmid><doi>10.1002/1097-0142(20000825)90:4<207::AID-CNCR2>3.0.CO;2-H</doi><tpages>8</tpages></addata></record> |
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| source | Wiley Free Content; Wiley Online Library - AutoHoldings Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - pathology Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma in Situ - pathology Cervical Intraepithelial Neoplasia - pathology Cervix Uteri - pathology Endometrial Neoplasms - pathology Endometrium - pathology Female Follow-Up Studies Genital system. Mammary gland Humans Hyperplasia - pathology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Middle Aged Ovarian Neoplasms - pathology Ovary - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Retrospective Studies Uterine Cervical Neoplasms - pathology Vaginal Smears |
| title | Atypical glandular cells of undetermined significance : Clinically significant lesions and means of patient follow-up |
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