Vaccination against nicotine during continued nicotine administration in rats: immunogenicity of the vaccine and effects on nicotine distribution to brain

Vaccination against nicotine has been proposed as a potential treatment for nicotine dependence. Because vaccination may take months to elicit satisfactory antibody levels, the clinical usefulness of this approach will be enhanced if vaccination can be accomplished during continued nicotine intake (...

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Veröffentlicht in:	International journal of immunopharmacology 2000-10, Vol.22 (10), p.809-819
Hauptverfasser:	Hieda, Y, Keyler, D.E, Ennifar, S, Fattom, A, Pentel, P.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Biological and medical sciences Brain - drug effects Brain - metabolism Dependence Enzyme-Linked Immunosorbent Assay Immunization Immunoglobulin E - immunology Injections, Subcutaneous Medical sciences Nicotine Nicotine - immunology Nicotine - pharmacokinetics Nicotine - pharmacology Nicotinic Agonists - immunology Nicotinic Agonists - pharmacology Pharmacokinetics Radioimmunoassay Rats Tobacco, tobacco smoking Toxicology Vaccination Vaccine
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