The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9
Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-targe...
Gespeichert in:
| Veröffentlicht in: | Cytogenetic and genome research 2000-01, Vol.89 (3-4), p.230-233 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 233 |
|---|---|
| container_issue | 3-4 |
| container_start_page | 230 |
| container_title | Cytogenetic and genome research |
| container_volume | 89 |
| creator | Gu, Z. Gilbert, D.J. Valentine, V.A. Jenkins, N.A. Copeland, N.G. Zambetti, G.P. |
| description | Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-target gene, EI24 (alias PIG8), induces apoptosis when ectopically expressed. To better understand the biological properties of EI24 and its potential relevance to disease, in particular cancer, we determined the chromosomal location and pattern of gene expression of EI24. EI24 is widely expressed in adult tissues and throughout mouse embryogenesis. The genomic locus of EI24 was mapped to the proximal region of mouse chromosome 9 and human chromosome 11q23→q24, a region frequently altered in human cancers. These results suggest that EI24 may play an important role in the p53 tumor suppressor pathway. |
| doi_str_mv | 10.1159/000015620 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72218474</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72218474</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-440a1f7d50b5ffa1cb4a868713c6987ecd9b2235e05dfd639e0478f5f9e9c7d03</originalsourceid><addsrcrecordid>eNptkc1rGzEQxUVpaD7aQ8-FIkII5LCNPnelYzCJYwikBxd6W7TSyN50d-VIXmjz10eOjRNKdJFgfnrz5g1CXyn5QanUlyQfKktGPqAjKpgolNS_P-7fih6i45QeMqSELD-hQ0p0KSknRyjOl4BXkhft4EbbNh3gBQyAr2dMXP6cTRXugjVd-wQJrwNejr0ZsF3G0IcUesCUPjKOzeDweiMUw9-2Nx2OsGjDgIPHfRgTvP2hP6MDb7oEX3b3Cfp1cz2f3BZ399PZ5OqusFyJdSEEMdRXTpJGem-obYRRpaoot6VWFVinG8a4BCKddyXXQESlvPQatK0c4SfofKubXT2OkNZ13yYLXWcGyKbqirGcRyUyePof-BDGOGRvNWOCcUJkmaGLLWRjSCmCr1cxjxr_1ZTUmy3U-y1k9vtOcGx6cG_IbewZONsBJuV0fTSDbdMrJ6QmdNPz2xb7Y-IC4mt91-X03epkMn0B6pXz_Bk0WKCB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>224230056</pqid></control><display><type>article</type><title>The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9</title><source>MEDLINE</source><source>Karger Journals</source><creator>Gu, Z. ; Gilbert, D.J. ; Valentine, V.A. ; Jenkins, N.A. ; Copeland, N.G. ; Zambetti, G.P.</creator><creatorcontrib>Gu, Z. ; Gilbert, D.J. ; Valentine, V.A. ; Jenkins, N.A. ; Copeland, N.G. ; Zambetti, G.P.</creatorcontrib><description>Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-target gene, EI24 (alias PIG8), induces apoptosis when ectopically expressed. To better understand the biological properties of EI24 and its potential relevance to disease, in particular cancer, we determined the chromosomal location and pattern of gene expression of EI24. EI24 is widely expressed in adult tissues and throughout mouse embryogenesis. The genomic locus of EI24 was mapped to the proximal region of mouse chromosome 9 and human chromosome 11q23→q24, a region frequently altered in human cancers. These results suggest that EI24 may play an important role in the p53 tumor suppressor pathway. </description><identifier>ISSN: 1424-8581</identifier><identifier>ISSN: 0301-0171</identifier><identifier>EISSN: 1424-859X</identifier><identifier>DOI: 10.1159/000015620</identifier><identifier>PMID: 10965130</identifier><identifier>CODEN: CGCGBR</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Apoptosis Regulatory Proteins ; Biological and medical sciences ; Blotting, Northern ; Chromosome Banding ; Chromosome Mapping ; Chromosomes - genetics ; Chromosomes, Human, Pair 11 - genetics ; Classical genetics, quantitative genetics, hybrids ; Embryo, Mammalian - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Genetics of eukaryotes. Biological and molecular evolution ; Human ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Mice, Inbred C57BL ; Muridae ; Nuclear Proteins - genetics ; Phosphoproteins - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Tissue Distribution ; Tumor Suppressor Protein p53 - physiology ; Vertebrata</subject><ispartof>Cytogenetic and genome research, 2000-01, Vol.89 (3-4), p.230-233</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel.</rights><rights>Copyright S. Karger AG 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-440a1f7d50b5ffa1cb4a868713c6987ecd9b2235e05dfd639e0478f5f9e9c7d03</citedby><cites>FETCH-LOGICAL-c384t-440a1f7d50b5ffa1cb4a868713c6987ecd9b2235e05dfd639e0478f5f9e9c7d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2423,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1459016$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10965130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gu, Z.</creatorcontrib><creatorcontrib>Gilbert, D.J.</creatorcontrib><creatorcontrib>Valentine, V.A.</creatorcontrib><creatorcontrib>Jenkins, N.A.</creatorcontrib><creatorcontrib>Copeland, N.G.</creatorcontrib><creatorcontrib>Zambetti, G.P.</creatorcontrib><title>The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9</title><title>Cytogenetic and genome research</title><addtitle>Cytogenet Genome Res</addtitle><description>Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-target gene, EI24 (alias PIG8), induces apoptosis when ectopically expressed. To better understand the biological properties of EI24 and its potential relevance to disease, in particular cancer, we determined the chromosomal location and pattern of gene expression of EI24. EI24 is widely expressed in adult tissues and throughout mouse embryogenesis. The genomic locus of EI24 was mapped to the proximal region of mouse chromosome 9 and human chromosome 11q23→q24, a region frequently altered in human cancers. These results suggest that EI24 may play an important role in the p53 tumor suppressor pathway. </description><subject>Animals</subject><subject>Apoptosis Regulatory Proteins</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Chromosome Banding</subject><subject>Chromosome Mapping</subject><subject>Chromosomes - genetics</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Muridae</subject><subject>Nuclear Proteins - genetics</subject><subject>Phosphoproteins - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Tissue Distribution</subject><subject>Tumor Suppressor Protein p53 - physiology</subject><subject>Vertebrata</subject><issn>1424-8581</issn><issn>0301-0171</issn><issn>1424-859X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkc1rGzEQxUVpaD7aQ8-FIkII5LCNPnelYzCJYwikBxd6W7TSyN50d-VIXmjz10eOjRNKdJFgfnrz5g1CXyn5QanUlyQfKktGPqAjKpgolNS_P-7fih6i45QeMqSELD-hQ0p0KSknRyjOl4BXkhft4EbbNh3gBQyAr2dMXP6cTRXugjVd-wQJrwNejr0ZsF3G0IcUesCUPjKOzeDweiMUw9-2Nx2OsGjDgIPHfRgTvP2hP6MDb7oEX3b3Cfp1cz2f3BZ399PZ5OqusFyJdSEEMdRXTpJGem-obYRRpaoot6VWFVinG8a4BCKddyXXQESlvPQatK0c4SfofKubXT2OkNZ13yYLXWcGyKbqirGcRyUyePof-BDGOGRvNWOCcUJkmaGLLWRjSCmCr1cxjxr_1ZTUmy3U-y1k9vtOcGx6cG_IbewZONsBJuV0fTSDbdMrJ6QmdNPz2xb7Y-IC4mt91-X03epkMn0B6pXz_Bk0WKCB</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Gu, Z.</creator><creator>Gilbert, D.J.</creator><creator>Valentine, V.A.</creator><creator>Jenkins, N.A.</creator><creator>Copeland, N.G.</creator><creator>Zambetti, G.P.</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9</title><author>Gu, Z. ; Gilbert, D.J. ; Valentine, V.A. ; Jenkins, N.A. ; Copeland, N.G. ; Zambetti, G.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-440a1f7d50b5ffa1cb4a868713c6987ecd9b2235e05dfd639e0478f5f9e9c7d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Apoptosis Regulatory Proteins</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Chromosome Banding</topic><topic>Chromosome Mapping</topic><topic>Chromosomes - genetics</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Muridae</topic><topic>Nuclear Proteins - genetics</topic><topic>Phosphoproteins - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Tissue Distribution</topic><topic>Tumor Suppressor Protein p53 - physiology</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gu, Z.</creatorcontrib><creatorcontrib>Gilbert, D.J.</creatorcontrib><creatorcontrib>Valentine, V.A.</creatorcontrib><creatorcontrib>Jenkins, N.A.</creatorcontrib><creatorcontrib>Copeland, N.G.</creatorcontrib><creatorcontrib>Zambetti, G.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Cytogenetic and genome research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gu, Z.</au><au>Gilbert, D.J.</au><au>Valentine, V.A.</au><au>Jenkins, N.A.</au><au>Copeland, N.G.</au><au>Zambetti, G.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9</atitle><jtitle>Cytogenetic and genome research</jtitle><addtitle>Cytogenet Genome Res</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>89</volume><issue>3-4</issue><spage>230</spage><epage>233</epage><pages>230-233</pages><issn>1424-8581</issn><issn>0301-0171</issn><eissn>1424-859X</eissn><coden>CGCGBR</coden><abstract>Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-target gene, EI24 (alias PIG8), induces apoptosis when ectopically expressed. To better understand the biological properties of EI24 and its potential relevance to disease, in particular cancer, we determined the chromosomal location and pattern of gene expression of EI24. EI24 is widely expressed in adult tissues and throughout mouse embryogenesis. The genomic locus of EI24 was mapped to the proximal region of mouse chromosome 9 and human chromosome 11q23→q24, a region frequently altered in human cancers. These results suggest that EI24 may play an important role in the p53 tumor suppressor pathway. </abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10965130</pmid><doi>10.1159/000015620</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1424-8581 |
| ispartof | Cytogenetic and genome research, 2000-01, Vol.89 (3-4), p.230-233 |
| issn | 1424-8581 0301-0171 1424-859X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72218474 |
| source | MEDLINE; Karger Journals |
| subjects | Animals Apoptosis Regulatory Proteins Biological and medical sciences Blotting, Northern Chromosome Banding Chromosome Mapping Chromosomes - genetics Chromosomes, Human, Pair 11 - genetics Classical genetics, quantitative genetics, hybrids Embryo, Mammalian - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Expression Regulation, Developmental Genetics of eukaryotes. Biological and molecular evolution Human Humans In Situ Hybridization, Fluorescence Male Mice Mice, Inbred C57BL Muridae Nuclear Proteins - genetics Phosphoproteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Tissue Distribution Tumor Suppressor Protein p53 - physiology Vertebrata |
| title | The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T19%3A12%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20p53-inducible%20gene%20EI24/PIG8%20localizes%20to%20human%20chromosome%2011q23%20and%20the%20proximal%20region%20of%20mouse%20chromosome%209&rft.jtitle=Cytogenetic%20and%20genome%20research&rft.au=Gu,%20Z.&rft.date=2000-01-01&rft.volume=89&rft.issue=3-4&rft.spage=230&rft.epage=233&rft.pages=230-233&rft.issn=1424-8581&rft.eissn=1424-859X&rft.coden=CGCGBR&rft_id=info:doi/10.1159/000015620&rft_dat=%3Cproquest_pubme%3E72218474%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=224230056&rft_id=info:pmid/10965130&rfr_iscdi=true |