$Evaluation of the antinociceptive action caused by ether fraction and a triterpene isolated from resin of Protium kleinii$

Evaluation of the antinociceptive action caused by ether fraction and a triterpene isolated from resin of Protium kleinii

This study investigates the antinociception caused by i.p. and p.o. administration of ether fraction and the triterpene identified as urs-12-ene-3β-16β-diol, known as Brein, isolated from Protium kleinii in several models of nociception in mice. The systemic administration of ether fraction (0.3 to...

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Veröffentlicht in:	Life sciences (1973) 2001-09, Vol.69 (19), p.2225-2236
Hauptverfasser:	Otuki, Michel F., Lima, Fabiana V., Malheiros, Angela, Cechinel-Filho, Valdir, Monache, Franco Delle, Yunes, Rosendo A., Calixto, João B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid test Analgesics - pharmacology Analgesics - therapeutic use Animals Antinociception Brein Capsaicin test Dose-Response Relationship, Drug Formalin test Glutamate test Hot-plate test Mice Pain - drug therapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Protium kleinii Resins, Plant - pharmacology Resins, Plant - therapeutic use Tail-flick test Triterpene Triterpenes - pharmacology Triterpenes - therapeutic use
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