Therapeutic efficacy of EGb761 (Gingko biloba extract) in a transgenic mouse model of amyotrophic lateral sclerosis

EGb761 is a standardized extract of green Gingko biloba, which exerts protective effects against mitochondrial damage and oxidative stress. We examined whether oral administration of 0.022% or 0.045% EGb761 in the diet could impart neuroprotective effects in a transgenic mouse model (G93A) of amyotr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular neuroscience 2001-08, Vol.17 (1), p.89-96
Hauptverfasser:	Ferrante, R J, Klein, A M, Dedeoglu, A, Beal, M F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - physiopathology Animals Body Weight Diet Disease Models, Animal Female Females Free Radical Scavengers - metabolism Free Radical Scavengers - therapeutic use Gender Ginkgo biloba Humans Lumbar Vertebrae Male Males Mice Mice, Transgenic Mitochondria Motor task performance Mutants Neurons - metabolism Neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use Oral administration Oxidative stress Phytotherapy Plant Extracts - administration & dosage Plant Extracts - therapeutic use Psychomotor Performance Rodents Rotation Spinal Cord - cytology Spinal Cord - pathology Superoxide Dismutase - genetics Superoxide Dismutase-1 Survival Survival Rate Transgenic mice Weight loss
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!