Controlled release of drugs from injectable in situ formed biodegradable PLGA microspheres: effect of various formulation variables

A novel in situ method for the preparation of injectable biodegradable poly(lactide-co-glycolide) (PLGA) microspheres for the controlled delivery of drugs is described here. A stable dispersion of PLGA microglobules (‘premicrospheres’ or ‘embryonic microspheres’) in a vehicle mixture on injection, c...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2000-09, Vol.50 (2), p.257-262
Hauptverfasser:	Jain, Rajeev A, Rhodes, Christopher T, Railkar, Aruna M, Malick, A.Waseem, Shah, Navnit H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Chemistry, Pharmaceutical Controlled release Drug Delivery Systems General pharmacology In situ Injections Lactic Acid - administration & dosage Mannitol - administration & dosage Medical sciences Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmaceutical Vehicles Pharmacology. Drug treatments Poly(lactide-co-glycolide) (PLGA) Polyethylene Glycols - administration & dosage Polyglycolic Acid - administration & dosage Polymers - administration & dosage Protein
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