Amrinone reduces ischaemia–reperfusion injury in rat heart

We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague–Dawley rats (150–275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30 μM) on left ventricular en...

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Veröffentlicht in:	European journal of pharmacology 2000-08, Vol.402 (3), p.255-262
Hauptverfasser:	Rechtman, Mary P, Van der Zypp, Andrea, Majewski, Henryk
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Amrinone Amrinone - pharmacology Animals Biological and medical sciences Cardiotonic Agents - pharmacology Cardiovascular system Creatine Kinase - metabolism Ischaemia L-Lactate Dehydrogenase - metabolism Male Medical sciences Milrinone - pharmacology Miscellaneous Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - pathology Myocardium - pathology Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology Rat Rats Rats, Sprague-Dawley Reperfusion injury Vasodilation - drug effects
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