Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death

Inhibitory regulators of apoptosis play a critical role in the responsiveness of tumour cells to cytotoxic agents. The X-linked inhibitor of apoptosis protein (XIAP) is a member of a novel family of Inhibitor of Apoptosis (IAP) proteins. Here we show that acute low dose ionizing irradiation results...

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Veröffentlicht in:	Oncogene 2000-08, Vol.19 (36), p.4174-4177
Hauptverfasser:	HOLCIK, M, YEH, C, KORNELUK, R. G, CHOW, T
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Antisense Elements (Genetics) Apoptosis Biological and medical sciences Cell death Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytotoxic agents Cytotoxicity Fundamental and applied biological sciences. Psychology Gamma Rays Humans IAP protein Lung cancer Lung carcinoma Molecular and cellular biology Non-small cell lung carcinoma Phenotypes Protein Biosynthesis Proteins - genetics Proteins - metabolism Radiation Ribosomes - genetics Small cell lung carcinoma Translation Tumor Cells, Cultured Tumors Up-Regulation X-Linked Inhibitor of Apoptosis Protein XIAP protein γ Radiation
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