HuR, a Protein Implicated in Oncogene and Growth Factor mRNA Decay, Binds to the 3′ Ends of Hepatitis C Virus RNA of Both Polarities

To identify cellular factors that interact with hepatitis C virus RNA, cellular extracts were subjected to UV cross-linking to radiolabeled RNAs corresponding to the hepatitis C virus 5′ and 3′ untranslated regions of positive and negative polarities. Our results demonstrate that the U-rich region o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2000-09, Vol.274 (2), p.378-390
Hauptverfasser:	Spångberg, Karin, Wiklund, Lisa, Schwartz, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Surface Base Sequence Binding Sites Cell Line cirrhosis ELAV Proteins ELAV-Like Protein 1 Genome, Viral Growth Substances - genetics HeLa Cells Hepacivirus - genetics Hepatitis C virus Heterogeneous-Nuclear Ribonucleoprotein Group C Heterogeneous-Nuclear Ribonucleoproteins hnRNP C protein hnRNP CN protein Humans HuR protein Molecular Weight mRNA decay Oncogenes - genetics Precipitin Tests Protein Binding Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Regulatory Sequences, Nucleic Acid - genetics Ribonucleoproteins - metabolism RNA Probes - genetics RNA Probes - metabolism RNA Stability RNA, Antisense - genetics RNA, Antisense - metabolism RNA, Viral - genetics RNA, Viral - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism Ultraviolet Rays Untranslated Regions - genetics Untranslated Regions - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!