The influence of traditional Chinese herbal drugs on serum 1,5-anhydroglucitol levels
The serum concentration of 1,5-anhydroglucitol (1,5-AG), a polyol which originates mainly in the diet, is used in Japan as a new marker for glycemia. To evaluate the potential interference of 1,5-AG measurements by traditional Chinese medicines (Kampo), we examined the 1,5-AG content in 32 types of...
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| Veröffentlicht in: | Diabetes research and clinical practice 2000-10, Vol.50 (2), p.97-101 |
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| creator | Kawasaki, Takahiro Yamanouchi, Toshikazu Kashiwabara, Akiko Inoue, Tae Yoshimura, Tomoe Fujimori, Sin Tanabe, Toshio Aiso, Yoshitaka |
| description | The serum concentration of 1,5-anhydroglucitol (1,5-AG), a polyol which originates mainly in the diet, is used in Japan as a new marker for glycemia. To evaluate the potential interference of 1,5-AG measurements by traditional Chinese medicines (Kampo), we examined the 1,5-AG content in 32 types of concentrated dosage forms of Kampo using high performance liquid chromatography (HPLC). The 32 types of Kampo were the most frequently used in Japan, two of which, Ninjin-yoei-to (7030 μg/g dry weight) and Kami-kihi-to (6700 μg/g dry weight), contained large amounts of 1,5-AG. Six others contained small amounts of 1,5-AG. Both Ninjin-yoei-to and Kami-kihi-to contain the same ingredient, Polygalae radix, which is a crude form of polygalitol (1,5-AG). To confirm the effects of these Kampo medicines on the serum levels of 1,5-AG, we administered Ninjin-yoei-to (7.5 g/day) for 8 weeks to 18 patients with Type 2 diabetes mellitus (Type 2 DM). The serum level of 1,5-AG increased from 9.8±8.9 to 28.1±17.5 μg/ml by week 8. Hemoglobin A1c (HbA1c) had not changed by week 8. Thus, an abnormal serum 1,5-AG level may be present in patients taking Kampo which contains Polygalae radix. |
| doi_str_mv | 10.1016/S0168-8227(00)00167-4 |
| format | Article |
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To evaluate the potential interference of 1,5-AG measurements by traditional Chinese medicines (Kampo), we examined the 1,5-AG content in 32 types of concentrated dosage forms of Kampo using high performance liquid chromatography (HPLC). The 32 types of Kampo were the most frequently used in Japan, two of which, Ninjin-yoei-to (7030 μg/g dry weight) and Kami-kihi-to (6700 μg/g dry weight), contained large amounts of 1,5-AG. Six others contained small amounts of 1,5-AG. Both Ninjin-yoei-to and Kami-kihi-to contain the same ingredient, Polygalae radix, which is a crude form of polygalitol (1,5-AG). To confirm the effects of these Kampo medicines on the serum levels of 1,5-AG, we administered Ninjin-yoei-to (7.5 g/day) for 8 weeks to 18 patients with Type 2 diabetes mellitus (Type 2 DM). The serum level of 1,5-AG increased from 9.8±8.9 to 28.1±17.5 μg/ml by week 8. Hemoglobin A1c (HbA1c) had not changed by week 8. Thus, an abnormal serum 1,5-AG level may be present in patients taking Kampo which contains Polygalae radix.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/S0168-8227(00)00167-4</identifier><identifier>PMID: 10960719</identifier><identifier>CODEN: DRCPE9</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>1,5-Anhydroglucitol ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - metabolism ; Deoxyglucose - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Drugs, Chinese Herbal - therapeutic use ; Endocrine glands ; Endocrinology ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Medicine, Kampo ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Polygalae radix ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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To evaluate the potential interference of 1,5-AG measurements by traditional Chinese medicines (Kampo), we examined the 1,5-AG content in 32 types of concentrated dosage forms of Kampo using high performance liquid chromatography (HPLC). The 32 types of Kampo were the most frequently used in Japan, two of which, Ninjin-yoei-to (7030 μg/g dry weight) and Kami-kihi-to (6700 μg/g dry weight), contained large amounts of 1,5-AG. Six others contained small amounts of 1,5-AG. Both Ninjin-yoei-to and Kami-kihi-to contain the same ingredient, Polygalae radix, which is a crude form of polygalitol (1,5-AG). To confirm the effects of these Kampo medicines on the serum levels of 1,5-AG, we administered Ninjin-yoei-to (7.5 g/day) for 8 weeks to 18 patients with Type 2 diabetes mellitus (Type 2 DM). The serum level of 1,5-AG increased from 9.8±8.9 to 28.1±17.5 μg/ml by week 8. Hemoglobin A1c (HbA1c) had not changed by week 8. Thus, an abnormal serum 1,5-AG level may be present in patients taking Kampo which contains Polygalae radix.</description><subject>1,5-Anhydroglucitol</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Deoxyglucose - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Endocrine glands</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine, Kampo</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Polygalae radix</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Traditional Chinese medicines</subject><subject>Type 2 diabetes mellitus</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlqHDEQQEWIscfLJyToEIwD6bjUq3QyZnAcg8GHzJyFWip5FDQtR-o2zN9bs5Dk5ksVVbxaeIR8YvCdAWuvf-XAC16W3RXAV8hVV9QfyIzxrty1P5LZX-SEnKb0GwDaqm6OyQkD0ULHxIwsFyukbrB-wkEjDZaOURk3ujAoT-crN2BCusLY59LE6TnRMNCEcVpT9q0p1LDamBie_aTdGDz1-Io-nZMjq3zCi0M-I8sfd4v5z-Lx6f5hfvtY6Lppx0KUWvc18go6jtoaxrE3WlQ9s0oJUTbCGC6QGyWsyFBrK6sqECBK7ACb6oxc7ve-xPBnwjTKtUsavVcDhinJrixZI-oqg80e1DGkFNHKl-jWKm4kA7n1KXc-5VaWBJA7n7LOc58PB6Z-jea_qb3ADHw5ACpp5W1Ug3bpH1fzbLzL2M0ey3Lw1WGUSbutceMi6lGa4N755A1mG5If</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Kawasaki, Takahiro</creator><creator>Yamanouchi, Toshikazu</creator><creator>Kashiwabara, Akiko</creator><creator>Inoue, Tae</creator><creator>Yoshimura, Tomoe</creator><creator>Fujimori, Sin</creator><creator>Tanabe, Toshio</creator><creator>Aiso, Yoshitaka</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>The influence of traditional Chinese herbal drugs on serum 1,5-anhydroglucitol levels</title><author>Kawasaki, Takahiro ; Yamanouchi, Toshikazu ; Kashiwabara, Akiko ; Inoue, Tae ; Yoshimura, Tomoe ; Fujimori, Sin ; Tanabe, Toshio ; Aiso, Yoshitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-92ccb4e83078ecfd18ebdc93b1faa99259dd89e8da9f93076f3fa309092e70e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>1,5-Anhydroglucitol</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Deoxyglucose - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Endocrine glands</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine, Kampo</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Polygalae radix</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Traditional Chinese medicines</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawasaki, Takahiro</creatorcontrib><creatorcontrib>Yamanouchi, Toshikazu</creatorcontrib><creatorcontrib>Kashiwabara, Akiko</creatorcontrib><creatorcontrib>Inoue, Tae</creatorcontrib><creatorcontrib>Yoshimura, Tomoe</creatorcontrib><creatorcontrib>Fujimori, Sin</creatorcontrib><creatorcontrib>Tanabe, Toshio</creatorcontrib><creatorcontrib>Aiso, Yoshitaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawasaki, Takahiro</au><au>Yamanouchi, Toshikazu</au><au>Kashiwabara, Akiko</au><au>Inoue, Tae</au><au>Yoshimura, Tomoe</au><au>Fujimori, Sin</au><au>Tanabe, Toshio</au><au>Aiso, Yoshitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of traditional Chinese herbal drugs on serum 1,5-anhydroglucitol levels</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>50</volume><issue>2</issue><spage>97</spage><epage>101</epage><pages>97-101</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><coden>DRCPE9</coden><abstract>The serum concentration of 1,5-anhydroglucitol (1,5-AG), a polyol which originates mainly in the diet, is used in Japan as a new marker for glycemia. To evaluate the potential interference of 1,5-AG measurements by traditional Chinese medicines (Kampo), we examined the 1,5-AG content in 32 types of concentrated dosage forms of Kampo using high performance liquid chromatography (HPLC). The 32 types of Kampo were the most frequently used in Japan, two of which, Ninjin-yoei-to (7030 μg/g dry weight) and Kami-kihi-to (6700 μg/g dry weight), contained large amounts of 1,5-AG. Six others contained small amounts of 1,5-AG. Both Ninjin-yoei-to and Kami-kihi-to contain the same ingredient, Polygalae radix, which is a crude form of polygalitol (1,5-AG). To confirm the effects of these Kampo medicines on the serum levels of 1,5-AG, we administered Ninjin-yoei-to (7.5 g/day) for 8 weeks to 18 patients with Type 2 diabetes mellitus (Type 2 DM). The serum level of 1,5-AG increased from 9.8±8.9 to 28.1±17.5 μg/ml by week 8. Hemoglobin A1c (HbA1c) had not changed by week 8. Thus, an abnormal serum 1,5-AG level may be present in patients taking Kampo which contains Polygalae radix.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10960719</pmid><doi>10.1016/S0168-8227(00)00167-4</doi><tpages>5</tpages></addata></record> |
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| subjects | 1,5-Anhydroglucitol Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Blood Glucose - metabolism Deoxyglucose - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Drugs, Chinese Herbal - therapeutic use Endocrine glands Endocrinology Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Medicine, Kampo Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polygalae radix Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Traditional Chinese medicines Type 2 diabetes mellitus |
| title | The influence of traditional Chinese herbal drugs on serum 1,5-anhydroglucitol levels |
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