Effects of selenium deficiency on the response of cardiac tissue to ischemia and reperfusion
Over a 10-week period, female Wistar rats received a diet containing a low level of selenium, cofactor of the antioxidant enzyme glutathione peroxidase (GPx) in order to examine the influence of deficiency of this trace element (i) on tissue antioxidant enzyme defence systems, and (ii) on the suscep...
Gespeichert in:
| Veröffentlicht in: | Toxicology (Amsterdam) 2000-08, Vol.148 (2), p.125-132 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 132 |
|---|---|
| container_issue | 2 |
| container_start_page | 125 |
| container_title | Toxicology (Amsterdam) |
| container_volume | 148 |
| creator | Toufektsian, Marie-Claire Boucher, François Pucheu, Sylvie Tanguy, Stéphane Ribuot, Christophe Sanou, Drissa Tresallet, Nicole de Leiris, Joël |
| description | Over a 10-week period, female Wistar rats received a diet containing a low level of selenium, cofactor of the antioxidant enzyme glutathione peroxidase (GPx) in order to examine the influence of deficiency of this trace element (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of global normothermic ischemia, followed by 30 min of reperfusion. The effects of selenium deficiency were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDevP, heart rate HR, and the product HR x LVDevP), as well as ultrastructural tissue characteristics. Furthermore, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured at the end of the reperfusion period. Results suggest that: (a) the activity of GPx is decreased by selenium deficiency while SOD activity remains unchanged, (b) the recovery of cardiac function and myocardial ventricular ultrastructure during reperfusion are altered in the selenium-deficient group compared to controls. These results illustrate the crucial role that selenium, the co-factor of one of the major antioxidant enzymes of the myocardium, plays in determining the vulnerability of the heart to ischemia and reperfusion. |
| doi_str_mv | 10.1016/S0300-483X(00)00203-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72215502</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0300483X00002031</els_id><sourcerecordid>72215502</sourcerecordid><originalsourceid>FETCH-LOGICAL-c518t-89e58cab1f1e5781aa661fbf53cf2b043f90e3bb6610f26e2a71fc005f6654d3</originalsourceid><addsrcrecordid>eNqF0c9rFTEQB_Agin1W_wQlByl6WM1sNtnsSaRUKxQ82IMHIWSzExrZ3Twzu0L_--b9QHt7p4HwmZkkX8Zeg_gAAvTHH0IKUTVG_nwnxHshaiEreMI2YNqukmDUU7b5R87YC6LfoijZ6OfsDESna5CwYb-uQkC_EE-BE444x3XiA4boI87-nqeZL3fIM9I2zYQ75l0eovN8iUQr8iXxSP4Op-i4m4dCt5jDSjHNL9mz4EbCV8d6zm6_XN1eXlc3379-u_x8U3kFZqlMh8p410MAVK0B57SG0Aclfah70cjQCZR9X05FqDXWroXghVBBa9UM8pxdHMZuc_qzIi12KjfCcXQzppVsW9egVHn7KQitBgPQnYZNmad0W6A6QJ8TUcZgtzlOLt9bEHaXk93nZHch2FL3OVkofW-OC9Z-wuFR1yGYAt4egSPvxpDd7CP9d6ou201hnw4My_f-jZgt7YPDIeYSqx1SPHGTBxpnrxs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14550567</pqid></control><display><type>article</type><title>Effects of selenium deficiency on the response of cardiac tissue to ischemia and reperfusion</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Toufektsian, Marie-Claire ; Boucher, François ; Pucheu, Sylvie ; Tanguy, Stéphane ; Ribuot, Christophe ; Sanou, Drissa ; Tresallet, Nicole ; de Leiris, Joël</creator><creatorcontrib>Toufektsian, Marie-Claire ; Boucher, François ; Pucheu, Sylvie ; Tanguy, Stéphane ; Ribuot, Christophe ; Sanou, Drissa ; Tresallet, Nicole ; de Leiris, Joël</creatorcontrib><description>Over a 10-week period, female Wistar rats received a diet containing a low level of selenium, cofactor of the antioxidant enzyme glutathione peroxidase (GPx) in order to examine the influence of deficiency of this trace element (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of global normothermic ischemia, followed by 30 min of reperfusion. The effects of selenium deficiency were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDevP, heart rate HR, and the product HR x LVDevP), as well as ultrastructural tissue characteristics. Furthermore, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured at the end of the reperfusion period. Results suggest that: (a) the activity of GPx is decreased by selenium deficiency while SOD activity remains unchanged, (b) the recovery of cardiac function and myocardial ventricular ultrastructure during reperfusion are altered in the selenium-deficient group compared to controls. These results illustrate the crucial role that selenium, the co-factor of one of the major antioxidant enzymes of the myocardium, plays in determining the vulnerability of the heart to ischemia and reperfusion.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(00)00203-1</identifier><identifier>PMID: 10962131</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cell metabolism, cell oxidation ; Cell physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Heart - drug effects ; Heart - physiopathology ; Heart Rate - drug effects ; Heart Ventricles - drug effects ; Heart Ventricles - physiopathology ; Heart Ventricles - ultrastructure ; Isolated rat heart ; Molecular and cellular biology ; Myocardial Ischemia - complications ; Myocardial Reperfusion Injury - etiology ; Myocardial Reperfusion Injury - physiopathology ; Myocardial Reperfusion Injury - prevention & control ; Myocardium - cytology ; Myocardium - enzymology ; Rats ; Rats, Wistar ; Reperfusion ; Selenium ; Selenium - administration & dosage ; Selenium - deficiency ; Superoxide Dismutase - metabolism</subject><ispartof>Toxicology (Amsterdam), 2000-08, Vol.148 (2), p.125-132</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-89e58cab1f1e5781aa661fbf53cf2b043f90e3bb6610f26e2a71fc005f6654d3</citedby><cites>FETCH-LOGICAL-c518t-89e58cab1f1e5781aa661fbf53cf2b043f90e3bb6610f26e2a71fc005f6654d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0300483X00002031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1526738$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10962131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toufektsian, Marie-Claire</creatorcontrib><creatorcontrib>Boucher, François</creatorcontrib><creatorcontrib>Pucheu, Sylvie</creatorcontrib><creatorcontrib>Tanguy, Stéphane</creatorcontrib><creatorcontrib>Ribuot, Christophe</creatorcontrib><creatorcontrib>Sanou, Drissa</creatorcontrib><creatorcontrib>Tresallet, Nicole</creatorcontrib><creatorcontrib>de Leiris, Joël</creatorcontrib><title>Effects of selenium deficiency on the response of cardiac tissue to ischemia and reperfusion</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Over a 10-week period, female Wistar rats received a diet containing a low level of selenium, cofactor of the antioxidant enzyme glutathione peroxidase (GPx) in order to examine the influence of deficiency of this trace element (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of global normothermic ischemia, followed by 30 min of reperfusion. The effects of selenium deficiency were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDevP, heart rate HR, and the product HR x LVDevP), as well as ultrastructural tissue characteristics. Furthermore, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured at the end of the reperfusion period. Results suggest that: (a) the activity of GPx is decreased by selenium deficiency while SOD activity remains unchanged, (b) the recovery of cardiac function and myocardial ventricular ultrastructure during reperfusion are altered in the selenium-deficient group compared to controls. These results illustrate the crucial role that selenium, the co-factor of one of the major antioxidant enzymes of the myocardium, plays in determining the vulnerability of the heart to ischemia and reperfusion.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell metabolism, cell oxidation</subject><subject>Cell physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Heart - drug effects</subject><subject>Heart - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Heart Ventricles - drug effects</subject><subject>Heart Ventricles - physiopathology</subject><subject>Heart Ventricles - ultrastructure</subject><subject>Isolated rat heart</subject><subject>Molecular and cellular biology</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Reperfusion Injury - etiology</subject><subject>Myocardial Reperfusion Injury - physiopathology</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Myocardium - cytology</subject><subject>Myocardium - enzymology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion</subject><subject>Selenium</subject><subject>Selenium - administration & dosage</subject><subject>Selenium - deficiency</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9rFTEQB_Agin1W_wQlByl6WM1sNtnsSaRUKxQ82IMHIWSzExrZ3Twzu0L_--b9QHt7p4HwmZkkX8Zeg_gAAvTHH0IKUTVG_nwnxHshaiEreMI2YNqukmDUU7b5R87YC6LfoijZ6OfsDESna5CwYb-uQkC_EE-BE444x3XiA4boI87-nqeZL3fIM9I2zYQ75l0eovN8iUQr8iXxSP4Op-i4m4dCt5jDSjHNL9mz4EbCV8d6zm6_XN1eXlc3379-u_x8U3kFZqlMh8p410MAVK0B57SG0Aclfah70cjQCZR9X05FqDXWroXghVBBa9UM8pxdHMZuc_qzIi12KjfCcXQzppVsW9egVHn7KQitBgPQnYZNmad0W6A6QJ8TUcZgtzlOLt9bEHaXk93nZHch2FL3OVkofW-OC9Z-wuFR1yGYAt4egSPvxpDd7CP9d6ou201hnw4My_f-jZgt7YPDIeYSqx1SPHGTBxpnrxs</recordid><startdate>20000807</startdate><enddate>20000807</enddate><creator>Toufektsian, Marie-Claire</creator><creator>Boucher, François</creator><creator>Pucheu, Sylvie</creator><creator>Tanguy, Stéphane</creator><creator>Ribuot, Christophe</creator><creator>Sanou, Drissa</creator><creator>Tresallet, Nicole</creator><creator>de Leiris, Joël</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope><scope>7X8</scope></search><sort><creationdate>20000807</creationdate><title>Effects of selenium deficiency on the response of cardiac tissue to ischemia and reperfusion</title><author>Toufektsian, Marie-Claire ; Boucher, François ; Pucheu, Sylvie ; Tanguy, Stéphane ; Ribuot, Christophe ; Sanou, Drissa ; Tresallet, Nicole ; de Leiris, Joël</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-89e58cab1f1e5781aa661fbf53cf2b043f90e3bb6610f26e2a71fc005f6654d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell metabolism, cell oxidation</topic><topic>Cell physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Heart - drug effects</topic><topic>Heart - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Heart Ventricles - drug effects</topic><topic>Heart Ventricles - physiopathology</topic><topic>Heart Ventricles - ultrastructure</topic><topic>Isolated rat heart</topic><topic>Molecular and cellular biology</topic><topic>Myocardial Ischemia - complications</topic><topic>Myocardial Reperfusion Injury - etiology</topic><topic>Myocardial Reperfusion Injury - physiopathology</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Myocardium - cytology</topic><topic>Myocardium - enzymology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion</topic><topic>Selenium</topic><topic>Selenium - administration & dosage</topic><topic>Selenium - deficiency</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toufektsian, Marie-Claire</creatorcontrib><creatorcontrib>Boucher, François</creatorcontrib><creatorcontrib>Pucheu, Sylvie</creatorcontrib><creatorcontrib>Tanguy, Stéphane</creatorcontrib><creatorcontrib>Ribuot, Christophe</creatorcontrib><creatorcontrib>Sanou, Drissa</creatorcontrib><creatorcontrib>Tresallet, Nicole</creatorcontrib><creatorcontrib>de Leiris, Joël</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toufektsian, Marie-Claire</au><au>Boucher, François</au><au>Pucheu, Sylvie</au><au>Tanguy, Stéphane</au><au>Ribuot, Christophe</au><au>Sanou, Drissa</au><au>Tresallet, Nicole</au><au>de Leiris, Joël</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of selenium deficiency on the response of cardiac tissue to ischemia and reperfusion</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2000-08-07</date><risdate>2000</risdate><volume>148</volume><issue>2</issue><spage>125</spage><epage>132</epage><pages>125-132</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>Over a 10-week period, female Wistar rats received a diet containing a low level of selenium, cofactor of the antioxidant enzyme glutathione peroxidase (GPx) in order to examine the influence of deficiency of this trace element (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of global normothermic ischemia, followed by 30 min of reperfusion. The effects of selenium deficiency were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDevP, heart rate HR, and the product HR x LVDevP), as well as ultrastructural tissue characteristics. Furthermore, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured at the end of the reperfusion period. Results suggest that: (a) the activity of GPx is decreased by selenium deficiency while SOD activity remains unchanged, (b) the recovery of cardiac function and myocardial ventricular ultrastructure during reperfusion are altered in the selenium-deficient group compared to controls. These results illustrate the crucial role that selenium, the co-factor of one of the major antioxidant enzymes of the myocardium, plays in determining the vulnerability of the heart to ischemia and reperfusion.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>10962131</pmid><doi>10.1016/S0300-483X(00)00203-1</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-483X |
| ispartof | Toxicology (Amsterdam), 2000-08, Vol.148 (2), p.125-132 |
| issn | 0300-483X 1879-3185 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72215502 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell metabolism, cell oxidation Cell physiology Female Fundamental and applied biological sciences. Psychology Glutathione peroxidase Glutathione Peroxidase - metabolism Heart - drug effects Heart - physiopathology Heart Rate - drug effects Heart Ventricles - drug effects Heart Ventricles - physiopathology Heart Ventricles - ultrastructure Isolated rat heart Molecular and cellular biology Myocardial Ischemia - complications Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - cytology Myocardium - enzymology Rats Rats, Wistar Reperfusion Selenium Selenium - administration & dosage Selenium - deficiency Superoxide Dismutase - metabolism |
| title | Effects of selenium deficiency on the response of cardiac tissue to ischemia and reperfusion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T01%3A14%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20selenium%20deficiency%20on%20the%20response%20of%20cardiac%20tissue%20to%20ischemia%20and%20reperfusion&rft.jtitle=Toxicology%20(Amsterdam)&rft.au=Toufektsian,%20Marie-Claire&rft.date=2000-08-07&rft.volume=148&rft.issue=2&rft.spage=125&rft.epage=132&rft.pages=125-132&rft.issn=0300-483X&rft.eissn=1879-3185&rft.coden=TXICDD&rft_id=info:doi/10.1016/S0300-483X(00)00203-1&rft_dat=%3Cproquest_cross%3E72215502%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14550567&rft_id=info:pmid/10962131&rft_els_id=S0300483X00002031&rfr_iscdi=true |